FlyBase Allele Report: Dmel\Fadd[RNAi.UASp.SN]

General Information

Symbol

Dmel\Fadd^RNAi.UASp.SN

Species

D. melanogaster

Name

FlyBase ID

FBal0290204

Feature type

allele

Associated gene

Dmel\Fadd

Associated Insertion(s)

Carried in Construct

P{UASp-Fadd.RNAi.SN}

Key Links

Transgenic product class

RNAi_reagent

(Naitza et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Naitza et al., 2002)

Mutagen

in vitro construct

(Naitza et al., 2002)

Progenitor genotype

Carried in construct

P{UASp-Fadd.RNAi.SN}

Cytology

Description

UASp sequences regulate expression of an inverted 500bp repeat fragment of Fadd coding sequence separated by the Chs2 intron.

(Naitza et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Fadd

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^yolk

(Naitza et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Fadd^{dsRNA.Scer\UAS.SN} Scer\GAL4^yolk female flies show a severe susceptibility to E.coli infection and close to wild type resistance to Gram-positive Streptococcus faecalis.

(Naitza et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fadd^RNAi.UASp.SN, Scer\GAL4^nub-AC-62 is a suppressor of increased cell death phenotype of RYBP^UAS.cBa, Scer\GAL4^nub-AC-62

(González and Busturia, 2009)

Fadd^RNAi.UASp.SN, Scer\GAL4^unspecified is a suppressor of abnormal size phenotype of RYBP^UAS.cBa, Scer\GAL4^unspecified

(González and Busturia, 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

Fadd^RNAi.UASp.SN, Scer\GAL4^nub-AC-62 is a suppressor of wing disc | third instar larval stage phenotype of RYBP^UAS.cBa, Scer\GAL4^nub-AC-62

(González and Busturia, 2009)

Fadd^RNAi.UASp.SN, Scer\GAL4^unspecified is a suppressor of wing phenotype of RYBP^UAS.cBa, Scer\GAL4^unspecified

(González and Busturia, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The increased apoptosis seen in Scer\GAL4^nub-AC-62 RYBP^Scer\UAS.cBa wing discs is completely inhibited by coexpression of Fadd^{dsRNA.Scer\UAS.SN}.

The small wing size seen in Scer\GAL4^unspecified RYBP^Scer\UAS.cBa wings is completely inhibited by coexpression of Fadd^{dsRNA.Scer\UAS.SN}.

(González and Busturia, 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Fadd^RNAi.UASp.SN

Fadd^{dsRNA.Scer\UAS.SN}

Fadd^{dsRNA.UASp.SN}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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