FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\WASpUAS.cBa
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General Information
Symbol
Dmel\WASpUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ben-Yaacov
FlyBase ID
FBal0121872
Feature type
allele
Associated gene
Dmel\WASp
Associated Insertion(s)
Carried in Construct
P{UAS-WASp.B}
Also Known As
UAS-WASp, UAS-Wsp
Key Links
Transgenic product class
cDNA
(Ben-Yaacov et al., 2001)
wild_type
(Ben-Yaacov et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ben-Yaacov et al., 2001)
wild_type
(Ben-Yaacov et al., 2001)
Mutagen
in vitro construct
(Ben-Yaacov et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-WASp.B}
Cytology
Description

UASt regulatory sequences drive expression of a full length WASp cDNA.

(Ben-Yaacov et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
WASp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTR406W.UAS
      (Duboff et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The mitochondria in the neurons of adult brains expressing WASpScer\UAS.cBa under the control of Scer\GAL4elav.PU are frequently elongated compared to controls.

      (Duboff et al., 2012)

      As in wild type, flies expressing WASpScer\UAS.cBa under the control of Scer\GAL4arm.PS in a WASp1/Df(3R)3450 mutant background display elongated cysts and a seminal vesicle that is full of individualised, mature sperm.

      (Rotkopf et al., 2011)

      Expression of WASpScer\UAS.cBa under the control of Scer\GAL4C57 has no effect on bouton number/muscle area or the number of satellite boutons at the third larval instar neuromuscular junction.

      (Nahm et al., 2010)

      Expression of WASpScer\UAS.cBa in the mesoderm under the control of Scer\GAL4twi.PG does not affect muscle development.

      (Schafer et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of both Cip4Scer\UAS.N.T:Ivir\HA1 and WASpScer\UAS.cBa under the control of Scer\GAL4C57 results in a reduction in bouton number/muscle area and in the number of satellite boutons at the third larval instar neuromuscular junction.

      (Nahm et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of WASpScer\UAS.cBa enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU.

      (Duboff et al., 2012)
      Complementation and Rescue Data
      Rescues

      WASpUAS.cBa/Scer\GAL4nSyb.PS rescues Df(3R)3450/WASp1

      (Khuong et al., 2010)

      Scer\GAL4twi.PG/WASpUAS.cBa rescues Df(3R)3450/WASp3D3-035

      (Schafer et al., 2007)

      WASpUAS.cBa/Scer\GAL4T80 rescues Df(3R)3450/WASp1

      (Tal et al., 2002)

      Scer\GAL4arm.PS/WASpUAS.cBa rescues Df(3R)3450/WASp1

      (Tal et al., 2002)

      WASpUAS.cBa/Scer\GAL4T80 rescues WASpunspecified

      (Ben-Yaacov et al., 2001)

      Scer\GAL4elav-C155/WASpUAS.cBa rescues WASpunspecified

      (Ben-Yaacov et al., 2001)

      Scer\GAL4arm.PS/WASpUAS.cBa rescues WASpunspecified

      (Ben-Yaacov et al., 2001)
      Partially rescues

      WASpUAS.cBa/Scer\GAL4elav.PLu partially rescues WASp1

      (Coyle et al., 2004)
      Fails to rescue

      Scer\GAL4kirre-rP298-G4/WASpUAS.cBa fails to rescue Df(3R)3450/WASp3D3-035

      (Schafer et al., 2007)
      Comments

      Expression of WASpScer\UAS.cBa under the control of Scer\GAL4n-syb.PS rescues the neuromuscular junction overgrowth seen in WASp1/Df(3R)3450 third instar larvae.

      (Khuong et al., 2010)

      Expression of WASpScer\UAS.cBa in WASp3D3-035/Df(3R)3450 mutants under the control of Scer\GAL4twi.PG restores almost the complete muscle pattern.

      Expression of WASpScer\UAS.cBa specifically in founder cells (under the control of Scer\GAL4kirre-rP298) in WASp3D3-035/Df(3R)3450 mutants does not restore a wild-type muscle pattern. Instead muscles look thinner compared to wild-type and some muscles are even missing.

      (Schafer et al., 2007)

      Expression of WASpScer\UAS.cBa under the control of Scer\GAL4elav.PLu partially rescues the neuromuscular junction defects of WASp1 mutants; normalised bouton number, NMJ length and branch number are significantly reduced towards wild-type levels.

      (Coyle et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      WASpScer\UAS.cBa
      WASpUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ben-Yaacov
      (Ben-Yaacov et al., 2001)
      Secondary FlyBase IDs
        References (12)