FB2026_02 , released June 18, 2026
Allele: Dmel\stnB6
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General Information
Symbol
Dmel\stnB6
Species
D. melanogaster
Name
FlyBase ID
FBal0122885
Feature type
allele
Associated gene
Dmel\stnB
Associated Insertion(s)
Carried in Construct
Also Known As
stnts
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: A104T.

    (Wall et al., 2005)

    This mutation (nucleotide substitution: A104T) creates an ectopic AUG at +103 bp.

    (Wall et al., 2005)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        stnB6/stnA6 is an enhancer of paralytic | heat sensitive phenotype of shi4

        (Stimson et al., 2001)

        stnB6/stnA6 is an enhancer of paralytic | heat sensitive phenotype of shi2

        (Stimson et al., 2001)
        NOT Enhancer of
        Statement
        Reference

        stnB6/stnA6 is a non-enhancer of paralytic | heat sensitive phenotype of comt6

        (Stimson et al., 2001)

        stnB6/stnA6 is a non-enhancer of paralytic | heat sensitive phenotype of parats1

        (Stimson et al., 2001)
        Other
        Statement
        Reference

        stnA6, stnB6 has decreased rate of movement phenotype

        (Stimson et al., 2001)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        stnB6/stnA6 is an enhancer of neuromuscular junction phenotype of shi2

        (Stimson et al., 2001)
        NOT Enhancer of
        Statement
        Reference

        stnA12, stnB6, stnA6, stnB12 is a non-enhancer of neuromuscular junction phenotype of shi2

        (Stimson et al., 2001)
        Other
        Statement
        Reference

        stnA6, stnB6 has neuromuscular junction & synaptic vesicle phenotype

        (Stimson et al., 2001)

        stnA12/stnA6, stnB6/stnB12 has neuromuscular junction & synaptic vesicle phenotype

        (Stimson et al., 2001)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        stnA6 stnB6 mutants show no decrease in synaptic vesicle density and no change in synaptic vesicle size at the larval neuromuscular junction (NMJ). Synaptic vesicle internalisation at the NMJ is delayed relative to wild type in stnA6 stnB6 mutants. The delay is even stronger in stnA6/stnA12 stnB6/stnB12 mutants. stnA6 stnB6 mutants are sluggish but do not show temperature-sensitive paralytic behaviour. At 28oC, stnA6 stnB6 mutant NMJs show only a marginal increase in the rate of synaptic depression as compared with wild type. The effect on depression remains slight even at 30oC. shi2 stnA6 stnB6 flies undergo complete paralysis in 2 minutes at 26oC. shi4 stnA6 stnB6 flies undergo complete paralysis in 2 minutes at 26oC. At 28oC, stnA6 stnB6 causes a marked enhancement of the weak neuromuscular junction depression seen in shi2 single mutants. At 30oC, there is no detectable effect of stnA6 stnB6 on depression.

        (Stimson et al., 2001)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Associated with: stnA6.

        (Stimson et al., 2001)
        Comments
        Comments

        The "stnts" mutation affects the levels of both stnA and stnB proteins at the larval neuromuscular junction; the mutation does not alter presynaptic levels of stnA protein consistently, although reduced levels are frequently seen, and a marked reduction in stnB protein levels is seen.

        (Stimson et al., 2001)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        stnts
        (Wall et al., 2005, Stimson et al., 2001)
        stnB6
        Name Synonyms
        Secondary FlyBase IDs
          References (2)