FlyBase Allele Report: Dmel\cas[3921]

General Information

Symbol

Dmel\cas³⁹²¹

Species

D. melanogaster

Name

FlyBase ID

FBal0123929

Feature type

allele

Associated gene

Dmel\cas

Associated Insertion(s)

P{GAL4}cas³⁹²¹

Carried in Construct

Also Known As

cas-Gal4, castor-GAL4

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hitier et al., 2001)

Mutagen

P-element activity

(Hitier et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{GAL4}cas³⁹²¹

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GAL4}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult mushroom body (with cas²⁹⁰)

(Hitier et al., 2001)

adult mushroom body beta'-lobe (with cas²⁹⁰)

(Hitier et al., 2001)

adult mushroom body beta-lobe (with cas²⁹⁰)

(Hitier et al., 2001)

Detailed Description

Statement

Reference

Homozygotes do not have any visible defects in the adult brain. cas²⁹⁰/cas³⁹²¹ escapers reveal mushroom bodies that lack β and β' lobes.

(Hitier et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

cas³⁹²¹, drl² has lethal phenotype

(Hitier et al., 2001)

cas³⁹²¹, drl^P1 has partially lethal phenotype

(Hitier et al., 2001)

cas³⁹²¹, drl^P3.765 has partially lethal phenotype

(Hitier et al., 2001)

cas³⁹²¹, drl² has partially lethal phenotype

(Hitier et al., 2001)

cas³⁹²¹, drl^P1 has viable | poor phenotype

(Hitier et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

cas³⁹²¹ is an enhancer of adult mushroom body beta'-lobe phenotype of drl^P1

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of adult mushroom body beta-lobe phenotype of drl^P1

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of adult brain phenotype of drl^P1

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of ellipsoid body phenotype of drl^P1

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of mushroom body phenotype of drl^P1

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of adult mushroom body beta'-lobe phenotype of drl^P3.765

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of adult mushroom body beta-lobe phenotype of drl^P3.765

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of adult brain phenotype of drl^P3.765

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of ellipsoid body phenotype of drl^P3.765

(Hitier et al., 2001)

cas³⁹²¹ is an enhancer of mushroom body phenotype of drl^P3.765

(Hitier et al., 2001)

Other

Statement

Reference

cas³⁹²¹, nob^KS49 has mushroom body phenotype

(Hitier et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

In drl^P1, cas³⁹²¹ and drl^P3.765, cas³⁹²¹ double mutants, fibres abnormally cross the midline above a flattened fan-shaped body in 55% of flies, the mushroom bodies β and β' lobes are fully fused in 33% of flies and the ellipsoid body is ventrally cleaved. In nob^KS49/cas³⁹²¹ flies, unlike the single mutants, individuals exhibit fibres abnormally crossing the midline above the fan shaped body.

(Hitier et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cas²⁹⁰

(Hitier et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cas³⁹²¹

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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