FlyBase Allele Report: Dmel\ey[ΔHD.UAS]

General Information

Symbol

Dmel\ey^ΔHD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0125070

Feature type

allele

Associated gene

Dmel\ey

Associated Insertion(s)

Carried in Construct

P{UAS-ey.ΔHD}

Key Links

Transgenic product class

inframe_deletion

(Punzo et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Punzo et al., 2001)

Mutagen

in vitro construct

(Punzo et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-ey.ΔHD}

Cytology

Description

UAS sequences drive expression of a mutated form of the E10 ey cDNA. This cDNA has had a BclI/VspI fragment deleted removing the HD domain.

(Punzo et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

antenna | ectopic, with Scer\GAL4^ey.PH, ey²

(Punzo et al., 2004)

eye, with Scer\GAL4^ey.PH, ey²

(Punzo et al., 2004)

eye | ectopic, with Scer\GAL4^dpp.blk1

(Punzo et al., 2004, Punzo et al., 2001)

eye | ectopic, with Scer\GAL4^dpp.blk1, ey²

(Punzo et al., 2001)

eye | ectopic, with Scer\GAL4^dpp.blk1, ey^J5.71

(Punzo et al., 2001)

Detailed Description

Statement

Reference

ey^{Scer\UAS.ΔHD}; Scer\GAL4^dpp.blk1 adults flies have ectopic eyes on various appendages. Expressivity of this phenotype varies depending on the P{UAS-ey.ΔHD} insertion used, correlating with the level of expression from the insertion.

(Punzo et al., 2004)

Expression of ey^{Scer\UAS.ΔHD} when driven by Scer\GAL4^dpp.blk1 leads to ectopic eyes. The addition of ey² or ey^J5.71 does not affect this phenotype.

(Punzo et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ey^ΔHD.UAS, Scer\GAL4^ey-OK107 is a suppressor of visible phenotype of Antp^UAS.cBa, Scer\GAL4^ey-OK107

(Plaza et al., 2008)

NOT Suppressor of

Statement

Reference

ey^ΔHD.UAS, Scer\GAL4^ey-OK107 is a non-suppressor of lethal phenotype of Antp^UAS.cBa, Scer\GAL4^ey-OK107

(Plaza et al., 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

ey^ΔHD.UAS is a suppressor | partially of eye phenotype of BacA\p35^UAS.cHa, Scer\GAL4^ey.PH, ey²

(Punzo et al., 2004)

ey^ΔHD.UAS is a suppressor | partially of antenna | ectopic phenotype of BacA\p35^UAS.cHa, Scer\GAL4^ey.PH, ey²

(Punzo et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Animals co-expressing ey^{ΔHD.Scer\UAS} and Antp^Scer\UAS.cBa under the control of Scer\GAL4^ey-OK107 show lethality such that few pupae are obtained. The few escapers show partial rescue of the eye loss caused by expression of Antp^Scer\UAS.cBa under the control of Scer\GAL4^ey-OK107.

(Plaza et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

ey^ΔHD.UAS/Scer\GAL4^ey.PH rescues ey^J5.71

(Punzo et al., 2001)

ey^ΔHD.UAS/Scer\GAL4^ey.PH rescues ey²

(Punzo et al., 2001)

Partially rescues

Scer\GAL4^ey-OK107/ey^ΔHD.UAS partially rescues ey^OK107-16/ey^JD

(Clements et al., 2009)

Scer\GAL4^ey-OK107/ey^ΔHD.UAS partially rescues ey^OK107-16/ey^EH

(Clements et al., 2009)

Comments

Expression of ey^{ΔHD.Scer\UAS} under the control of Scer\GAL4^ey-OK107 partially rescues the eye defects, but does not rescue the mushroom body or central complex defects, of ey^EH/ey^OK107-16 mutants.

Expression of ey^{ΔHD.Scer\UAS} under the control of Scer\GAL4^ey-OK107 rescues the mushroom body and central complex defects, and partially rescues the eye defects, of ey^JD/ey^OK107-16 mutants.

(Clements et al., 2009)

ey^{Scer\UAS.ΔHD} (driven by Scer\GAL4^ey.PH) rescues ey² at an even higher efficiency than wild-type ey.

(Punzo et al., 2001)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ey^{Scer\UAS.ΔHD}

ey^{ΔHD.Scer\UAS}

ey^ΔHD.UAS

eyΔHD

(Plaza et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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