FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\easalaP
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General Information
Symbol
Dmel\easalaP
Species
D. melanogaster
Name
FlyBase ID
FBal0125158
Feature type
allele
Associated gene
Dmel\eas
Associated Insertion(s)
P{GawB}easalaP
Carried in Construct
Also Known As
ala1
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Pascual et al., 2005, Boquet et al., 2000)
Mutagen
Delta2-3 transposase
(Boquet et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{GawB}easalaP
Cytology
Description

The P{GawB} element insertion is at nucleotide 38 of the eas gene.

(Pascual et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ten-day old easalaP flies (of either sex) do not exhibit signs of retinal degeneration.

      (Kristaponyte et al., 2012)

      easalaP mutants show no bang-sensitive phenotype, either as homozygotes or as transheterozygotes with eas2 or Df(1)4b18. easalaP mutants have a range of defects in the mushroom body; 36% lack β' and β lobes in both hemispheres, 4.5% lack α' and α vertical lobes in both hemispheres, while 10.5% possess all five lobes in both hemispheres. The remaining flies have different combinations of mushroom body phenotype in the left and right hemisphere. The neuroblasts of eas2 mutants show reduced mitosis in mushroom bodies at the pupal stage. This defect leads to a smaller calyx size than in wild-type flies at the adult stage.

      (Pascual et al., 2005)

      Homozygous flies show fusion of both β and β' lobes with intermediate frequency and a reduction or absence of the α lobes in the central brain. easalaP/Df(1)4b18 adults show a very high frequency of β lobe fusion in the central brain. α lobes are absent. Heterozygotes have no adult central brain defect.

      (Boquet et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{GawB} element can revert the mutant phenotype.

      (Boquet et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ala
      (Boquet et al., 2000)
      ala1
      (Kristaponyte et al., 2012, van Swinderen, 2007, Pascual and Preat, 2001)
      alaP
      easalaP
      (Lim et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)