FlyBase Allele Report: Dmel\Pka-C1[BG02142]

General Information

Symbol

Dmel\Pka-C1^BG02142

Species

D. melanogaster

Name

FlyBase ID

FBal0125374

Feature type

allele

Associated gene

Dmel\Pka-C1

Associated Insertion(s)

P{GT1}Pka-C1^BG02142

Carried in Construct

Also Known As

BG02142

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{GT1}Pka-C1^BG02142

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GT1}

gene trap

polyA trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:9,699,218..9,699,218 [+]

(Huang et al., 2025, Chen et al., 2014, Chen and Ganetzky, 2012, Tunstall et al., 2012, Dworkin and Gibson, 2006, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Tunstall et al., 2012)

lethal | recessive

(Dworkin and Gibson, 2006)

lethal - all die before end of pupal stage

(Chen et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Pka-C1^BG02142 is homozygous lethal.

(Tunstall et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Pka-C1[+]/Pka-C1^BG02142 is an enhancer of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

Other

Statement

Reference

Df(1)Exel9051/+, Pka-C1^BG02142 has abnormal neuroanatomy | third instar larval stage phenotype

(Chen and Ganetzky, 2012)

Phenotype Manifest In

Other

Statement

Reference

Df(1)Exel9051/+, Pka-C1^BG02142 has NMJ bouton | third instar larval stage phenotype

(Chen and Ganetzky, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for both Pka-C1^BG02142 and Df(1)Exel9051 results in a significant reduction in neuromuscular junction (NMJ) synaptic bouton numbers, compared with either single mutant or wild-type.

(Chen and Ganetzky, 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Pka-C1^unspecified

(Dworkin and Gibson, 2006)

Comments

Images (0)

Mutant

Wild-type