FlyBase Allele Report: Dmel\rasp[T392]

General Information

Symbol

Dmel\rasp^T392

Species

D. melanogaster

Name

FlyBase ID

FBal0126335

Feature type

allele

Associated gene

Dmel\rasp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q287term.

(Lee and Treisman, 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:3,163,057..3,163,057 [+]

Nucleotide change:

C3163057T

Amino acid change:

Q287term | rasp-PA

Reported amino acid change:

Q287term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lee and Treisman, 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage | recessive

(Lee and Treisman, 2001)

some die during pupal stage | recessive

(Lee and Treisman, 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

While no photoreceptors form in rasp homozygous mutant eye discs, photoreceptor R8 differentiation is normal in small rasp^T392 homozygous clones. However, recruitment and differentiation of photoreceptors R1-R7 is defective in these clones.

Adult wings containing rasp^T392 homozygous somatic clones often have gaps in veins.

(Miura et al., 2006)

rasp^T392/rasp^T802 eye discs are smaller than wild-type.

(Lee and Treisman, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

rasp^T392 has photoreceptor cell R7 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

rasp^T392 has photoreceptor cell R6 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

rasp^T392 has photoreceptor cell R5 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

rasp^T392 has photoreceptor cell R4 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

rasp^T392 has photoreceptor cell R3 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

rasp^T392 has photoreceptor cell R2 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

rasp^T392 has photoreceptor cell R1 | somatic clone | third instar larval stage phenotype, non-suppressible by aos^Δ7/aos^Δ7

(Miura et al., 2006)

Suppressor of

Statement

Reference

rasp^T392/rasp^T802 is a suppressor of eye photoreceptor cell | ectopic | somatic clone phenotype of ptc^S2

(Miura et al., 2006)

rasp^T392/rasp^T802 is a suppressor of eye photoreceptor cell | somatic clone phenotype of Scer\GAL4^Act5C.PP, rho^UAS.cGa, spi^s.UAS

(Miura et al., 2006)

rasp^T392/rasp^T802 is a suppressor of eye photoreceptor cell | somatic clone phenotype of Scer\GAL4^Act5C.PP, rho^UAS.cGa, spi^s.UAS.EGFP

(Miura et al., 2006)

NOT Suppressor of

Statement

Reference

rasp^T392/rasp^T802 is a non-suppressor of photoreceptor neuron | ectopic | somatic clone phenotype of Scer\GAL4^Act5C.PP, btl::Egfr^λ.UAS

(Miura et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Most ectopic photoreceptor differentiation caused by ptc^S2 homozygous clones in the eye disc is suppressed in a rasp^T392/rasp^T802 background, with most of the remaining photoreceptors having R8 identity.

Recruitment and differentiation of R1-R7 photoreceptor cells in rasp^T392 homozygous clones is not rescued by argos^Δ7 homozygous background.

The ectopic photoreceptor differentiation induced by somatic clones of Scer\GAL4^Act5C.PP cells in the eye disc in animals carrying rho^Scer\UAS.cGa and spi^s.Scer\UAS or spi^{Scer\UAS.s.T:Avic\GFP} is completely suppressed by rasp^T392/rasp^T802. However, the ectopic photoreceptor differentiation caused by somatic clones of Scer\GAL4^Act5C.PP cells in the eye disc in animals carrying btl::Egfr^{Scer\UAS.T:λ\cI-DD} is not suppressed by rasp^T392/rasp^T802.

(Miura et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63803

w^*; rasp^T392 P{neoFRT}80B/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

rasp^T392

(Miura et al., 2006)

sit^T392

(Lee and Treisman, 2001)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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