FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\domeG0217
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General Information
Symbol
Dmel\domeG0217
Species
D. melanogaster
Name
FlyBase ID
FBal0126402
Feature type
allele
Associated gene
Dmel\dome
Associated Insertion(s)
P{lacW}domeG0217
Carried in Construct
Also Known As
dome217
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Castelli-Gair Hombria, 2001.9.19)
Mutagen
P-element activity
(Peter et al., 2002, Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19)
Progenitor genotype
Associated Insertion(s)
P{lacW}domeG0217
Cytology
Description

The P{lacW} insertion is at nucleotide +168 of the 4.8kb dome transcript.

(Josten et al., 2004)

P{lacW} insertion in the 5' UTR, at nucleotide position 154 of dome EST LD32858.

(Brown et al., 2001)

Insertion of P{lacW} into 5' UTR of dome, at position of 154bp with respect to the start of LD32858.

(Castelli-Gair Hombria, 2001.9.19)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ427011
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      domeG0217 mutants show premature differentiation to P1+ plasmatocytes.

      (Sinha et al., 2013)

      Mutant animals are lethal at the first instar larval stage and show a phenotype in the gastrointestinal tract indicate by a block of food passage at the defective proventriculus organ. A failure of ectodermal cells to invaginate and a disorganised endodermal layer of the proventriculus is seen. The proventriculus development is normal in early stages of proventriculus development in mutants. However in the keyhole stage, the anterior boundary cells fail to move inward into the endodermal keyhole domain and arrest anterior to the proventricular endoderm until late stages of embryonic development. Furthermore, the endodermal cell layer of the keyhole is disorganised and the proventriculus is collapsed.

      (Josten et al., 2004)

      Homozygous embryos lack filzkorper.

      (Brown et al., 2003)

      Lethality occurs during the embryonic stage and the first larval instar.

      (Peter et al., 2002)

      The shape of the posterior spiracles is affected in mutants. Homozygous embryos derived from homozygous female germline clones have segmentation defects, such as deletion of segment A5 and most of the A4 denticle belts, partial or total fusion of segments A6 and A7 and a variable reduction of the thoracic segments and A8.

      (Brown et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The enlarged eye phenotype seen in flies carrying one copy of upd1GMR.PB is moderately suppressed by one copy of domeG0217.

      (Bach et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mobilisation of the P-element reverts both the lethality and posterior spiracle phenotype.

      (Brown et al., 2001)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      dome217
      (Sinha et al., 2013)
      dome217
      (Hombria et al., 2005, Bach et al., 2003, Brown et al., 2003, Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19)
      domeG0217
      l(1)G0217
      (Peter et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)