FlyBase Allele Report: Dmel\dome[unspecified]

General Information

Symbol

Dmel\dome^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0128000

Feature type

allele

Associated gene

Dmel\dome

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Chen et al., 2002)

some die during larval stage | recessive

(Chen et al., 2002)

visible | germline clone

(Hombria et al., 2005)

Phenotype Manifest In

border follicle cell

(Ghiglione et al., 2002)

mouth hook | germline clone

(Hombria et al., 2005)

posterior spiracle primordium | germline clone

(Hombria et al., 2005)

presumptive embryonic/larval tracheal system | germline clone

(Brown et al., 2001)

tracheal branch primordium | germline clone

(Hombria et al., 2005)

Detailed Description

Statement

Reference

In dome^unspecified embryos from germ-line clones, the posterior spiracles and trachea are missing and the mandible is abnormal.

(Hombria et al., 2005)

Heterozygotes show defects in border follicle cell migration.

(Ghiglione et al., 2002)

The trachea do not develop in embryos lacking maternal and zygotic dome function.

(Brown et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

dome^unspecified is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, tkv^{Q253D.UAS.cLa}

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

dome^unspecified is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, tkv^{Q253D.UAS.cLa}

(Bach et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

dome^unspecified has border follicle cell phenotype, enhanceable by Stat92E^unspecified/Stat92E[+]

(Ghiglione et al., 2002)

Suppressed by

Statement

Reference

dome^unspecified has border follicle cell phenotype, suppressible by Su(var)2-10[+]/Su(var)2-10^unspecified

(Ghiglione et al., 2002)

NOT Enhancer of

Statement

Reference

dome^unspecified is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, tkv^{Q253D.UAS.cLa}

(Bach et al., 2003)

Suppressor of

Statement

Reference

dome^unspecified is a suppressor | partially of embryonic head phenotype of Scer\GAL4^h-1J3, upd1^UAS.cZa

(Brown et al., 2001)

NOT Suppressor of

Statement

Reference

dome^unspecified is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, tkv^{Q253D.UAS.cLa}

(Bach et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The border cell migration defects of dome^unspecified heterozygotes are enhanced by one copy of Stat92E^unspecified and suppressed by one copy of Su(var)2-10^unspecified.

(Ghiglione et al., 2002)

Abnormal head development is seen in only 16% of embryos expressing upd1^Scer\UAS.cZa under the control of Scer\GAL4^h-1J3 which are also mutant for dome^unspecified.

(Brown et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

dome^unspecified is not rescued by dome^ΔTMCYT.UAS/Scer\GAL4^unspecified

(Brown et al., 2001)

dome^unspecified is not rescued by dome^ΔCYT.UAS/Scer\GAL4^unspecified

(Brown et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dome^unspecified

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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