FlyBase Allele Report: Dmel\gish[1]

General Information

Symbol

Dmel\gish¹

Species

D. melanogaster

Name

FlyBase ID

FBal0130264

Feature type

allele

Associated gene

Dmel\gish

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

An insertion of DNA of unknown origin is located 5' to the CKIγa transcript start site.

(Hummel et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Hummel et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

gish¹ mutant larvae exhibit a glial cell migration phenotype in the developing eye. Surface glial cells migrate precociously into the eye disc, along the basal surface of the eye disc and in contrast to wild-type, continue to migrate past the morphogenetic furrow (MF) into anterior part of the disc. R cell axons project to the basal surface of the eye disc, as normal, but then turn towards the MF, rather than posteriorly as in wild-type. In all, cases the axons migrate between ectopic glial cells and the basal surface of the eye disc. Adult eyes are smaller than wild-type and often contain a reduced number of ommatidia in the anterior region. Homozygous mutant somatic clones in the eye also give the same phenotypes. Only minor defects are seen MF progression.

(Hummel et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

gish¹ has light-sensitive neuron phenotype, enhanceable by so¹

(Hummel et al., 2002)

gish¹ has light-sensitive neuron phenotype, enhanceable by ey¹

(Hummel et al., 2002)

Suppressed by

Statement

Reference

gish¹ has lamina anlage glial cell | ectopic phenotype, suppressible by hh^UAS.cPb/Scer\GAL4^dpp.blk1

(Hummel et al., 2002)

gish¹ has adult subretinal glial cell | ectopic phenotype, suppressible by hh^UAS.cPb/Scer\GAL4^dpp.blk1

(Hummel et al., 2002)

NOT suppressed by

Statement

Reference

gish¹ has adult subretinal glial cell | ectopic phenotype, non-suppressible by eya²

(Hummel et al., 2002)

gish¹ has lamina anlage glial cell | ectopic phenotype, non-suppressible by eya²

(Hummel et al., 2002)

gish¹ has lamina anlage | ectopic phenotype, non-suppressible by eya²

(Hummel et al., 2002)

Enhancer of

Statement

Reference

gish¹ is an enhancer of light-sensitive neuron phenotype of so¹

(Hummel et al., 2002)

gish¹ is an enhancer of light-sensitive neuron phenotype of ey¹

(Hummel et al., 2002)

gish¹ is an enhancer of light-sensitive neuron phenotype of so⁵

(Hummel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

gish¹ is partially rescued by gish^UAS.cHa/Scer\GAL4^dpp.blk1

(Hummel et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

gish¹

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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