FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\so5
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General Information
Symbol
Dmel\so5
Species
D. melanogaster
Name
FlyBase ID
FBal0035652
Feature type
allele
Associated gene
Dmel\so
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kenyon et al., 2005)

loss of function allele

(Cheyette et al., 1994)
Mutagen
ethyl methanesulfonate
(Roote, 1995.9.26, Cheyette et al., 1994, Heitzler et al., 1993)
Progenitor genotype
Cytology
Description

Amino acid replacement: D217N.

(Kenyon et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,425,251..7,425,251 [+]
Nucleotide change:

G7425251A

Amino acid change:

D217N | so-PA

Reported amino acid change:

D217N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kenyon et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      so5 flies have eyes that are slightly reduced compared to wild type, but have normal ocelli.

      (Kenyon et al., 2005)

      Homozygous mutant larvae exhibit an early onset glial cell migration defect in the developing eye.

      (Hummel et al., 2002)

      Homozygotes have slightly reduced and roughened eyes due to marked reduction in the number of ommatidia and disorganised ommatidial array. Homozygous eye discs display massive cell death anterior to the morphogenetic furrow. so3/so5 transheterozygotes exhibit an extreme eye phenotype. The optic lobe primordium of homozygotes is reduced in size and movement into the head cavity is arrested at an early stage so it fails to invaginate.

      (Cheyette et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      so5 has photoreceptor neuron phenotype, enhanceable by gish1

      (Hummel et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      so3/so5 is rescued by sohs.PC

      (Cheyette et al., 1994)
      Comments

      so3/so5 eye phenotype can be rescued by heat induced expression of so.

      (Cheyette et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      2AA
      (Roote, 1995.9.26)
      SO5
      (Kenyon et al., 2005)
      so5
      Name Synonyms
      Secondary FlyBase IDs
        References (6)