Open Close
General Information
Symbol
Dmel\so3
Species
D. melanogaster
Name
FlyBase ID
FBal0035650
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

1.0kb deletion that removes the second exon, including the initiating ATG.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Approximately 80% of flies containing so3 mutant clones can eclose as adults. The flies have small or no eyes, but normal antennae and palp. Head cuticle with antenna-like structures can extend into the eye and some of the small eyes become club-like, suggesting a partial transformation to antenna. Occasional loss of the ocellus is also seen.

so3 mutants do not develop a somatogastric nervous system. However, this does not affect the formation of the pars intercerebralis.

so3 mutant clones in the eye over-proliferate and are non-autonomous.

The stomatogastric nervous system and corpus cardiacum are absent in mutant stage 16 embryos.

Heterozygotes have wild-type eyes.

so9/so3 adult males are viable and fertile, and have normal looking testes with no degenerating spermatocytes.

When clones of so3 homozygous cells are induced in the testis, spermatocyte degeneration is seen. However, this degeneration appears to be independent of the genotype of the spermatocytes in question, suggesting that it is the genotype of cyst cells (not scoreable for technical reasons) that is important in determining spermatocyte degeneration.

Stalk cells are missing in mutant egg chambers.

Bolwig's organ neurons are missing in mutant embryos.

Development of the visual system proceeds normally in mutant embryos until stage 11, when the posterior lip of the optic lobe would normally start to invaginate. Invagination of the optic lobe placode does not occur in mutant embryos.

Cells of homozygous clones in the eye disc overproliferate and fail to differentiate into neurons. The clones retain their epithelial organisation and give rise to abnormal folding of the disc. Cells in the clones subsequently die. Morphogenetic furrow initiation does not occur in clones of the eye disc that encompass the margins. Propagation of the morphogenetic furrow does not occur in homozygous clones in the eye disc. 3% of the R1, R6 and R7 cells are missing in eyes in which homozygous clones have been induced using Scer\FLP1GMR.PP.

so3/so5 transheterozygotes exhibit an extreme eye phenotype, The optic lobe primordium of homozygotes is reduced in size and movement into the head cavity is arrested at an early stage so it fails to invaginate.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

so[+]/so3 is an enhancer of visible | recessive phenotype of ey2

NOT Enhancer of
Statement
Reference

so[+]/so3 is a non-enhancer of abnormal size | adult stage phenotype of CtBPGSA396, Scer\GAL4ey.PU

so[+]/so3 is a non-enhancer of visible | adult stage phenotype of CtBPGSA396, Scer\GAL4ey.PU

NOT Suppressor of
Statement
Reference

so[+]/so3 is a non-suppressor of abnormal size | adult stage phenotype of CtBPGSA396, Scer\GAL4ey.PU

so[+]/so3 is a non-suppressor of visible | adult stage phenotype of CtBPGSA396, Scer\GAL4ey.PU

Phenotype Manifest In
NOT suppressed by
Statement
Reference

so3 has Bolwig organ phenotype, non-suppressible by hhUAS.cKa/Scer\GAL4h-1J3

Enhancer of
Statement
Reference

so[+]/so3 is an enhancer of eye phenotype of ey2

NOT Enhancer of
Statement
Reference

so[+]/so3 is a non-enhancer of eye phenotype of CtBPGSA396, Scer\GAL4ey.PU

Suppressor of
Statement
Reference

so3 is a suppressor | partially of wing phenotype of Scer\GAL4dpp.PH, eyaUAS.cHa

NOT Suppressor of
Statement
Reference

so[+]/so3 is a non-suppressor of eye phenotype of CtBPGSA396, Scer\GAL4ey.PU

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Significant levels of spermatocyte degeneration is seen in the testes of Df(2L)eya10 so9/so3 adults and pharate adults.

The proportion of eyaScer\UAS.cHa; Scer\GAL4dpp.PH flies with blistered wings (76%) is decreased by heterozygosity for so3 to 17%, while the proprotion with only mild wing defects is increased from 24% to 83%. (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

The so3 Bolwig's organ phenotype is not rescued by expression of hhScer\UAS.cKa under the control of Scer\GAL4h-1J3.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by
Comments

The lack of Bolwig's organ neurons seen in so3 embryos is partially rescued by soScer\UAS.cPa expressed under the control of Scer\GAL4h-1J3.

so3/so5 eye phenotype can be rescued by heat induced expression of so (repetitive heat shocks during third instar).

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (33)