FlyBase Allele Report: Dmel\ytr[5E24]

General Information

Symbol

Dmel\ytr^5E24

Species

D. melanogaster

Name

FlyBase ID

FBal0133956

Feature type

allele

Associated gene

Dmel\ytr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sinenko et al., 2004)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T?A.

(Sinenko et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval crystal cell | increased number

(Sinenko et al., 2004)

embryonic/larval hemocyte | increased number

(Sinenko and Mathey-Prevot, 2004)

embryonic/larval lymph gland

(Sinenko et al., 2004)

hemocyte

(Sinenko et al., 2004)

hemocyte & nucleus | supernumerary

(Sinenko et al., 2004)

hemocyte | increased number

(Sinenko et al., 2004)

lamellocyte | increased number

(Sinenko et al., 2004)

Detailed Description

Statement

Reference

Homozygous larvae show an increase in the number of hemocytes compared to control larvae.

(Sinenko and Mathey-Prevot, 2004)

Homozygous mutant larvae exhibit a marked elevation (4 fold) in circulating hemocytes. The proportion of lamellocytes (25%) is greatly increased compared to wild-type (0.3%). Mutant animals exhibit a marked enlargement of the first lobes of the lymph gland, which occasionally contain melanised hemocytes. In addition hemocytes are larger and more heterogeneous in size and shape than those found in wild-type. Many of the larger rounder hemocytes in the lymph glands and in circulation (up to 10% of all hemocytes) contain two nuclei. Up to 20% of lamellocytes also have crystal cells.

(Sinenko et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

ytr^5E24 has embryonic/larval hemocyte | increased number phenotype, suppressible by Tsp68C^+t3.0

(Sinenko and Mathey-Prevot, 2004)