FlyBase Allele Report: Dmel\mask[6.3]

General Information

Symbol

Dmel\mask^6.3

Species

D. melanogaster

Name

FlyBase ID

FBal0134055

Feature type

allele

Associated gene

Dmel\mask

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Smith et al., 2002)

Mutagen

ethyl methanesulfonate

(Smith et al., 2002)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | larval stage (with mask^7.29)

(Smith et al., 2002)

increased cell death (with mask^7.29)

(Smith et al., 2002)

lethal - all die before end of larval stage (with mask^7.29)

(Smith et al., 2002)

some die during larval stage (with mask^7.29)

(Smith et al., 2002)

Phenotype Manifest In

eye-antennal disc (with mask^7.29)

(Smith et al., 2002)

larval digestive system (with mask^7.29)

(Smith et al., 2002)

ommatidial precursor cluster (with mask^7.29)

(Smith et al., 2002)

photoreceptor cell R7 | somatic clone

(Smith et al., 2002)

photoreceptor neuron | somatic clone

(Smith et al., 2002)

Detailed Description

Statement

Reference

Some mask^7.29/mask^6.3 animals survive to the third larval instar. These larvae are significantly smaller than wild-type third instar larvae and have smaller eye-antennal discs than normal. The progression of the morphogenetic furrow does occur in these discs and some photoreceptor differentiation is seen posterior to the furrow, although many ommatidia do not contain the normal number of photoreceptor cells. The eye imaginal discs, alimentary canal and many other tissues show an elevated level of apoptosis. Adult flies show loss of outer and inner photoreceptor cells within many ommatidia in homozygous clones. The number of homozygous R7 cells in mosaic ommatidia containing both wild-type and homozygous cells is reduced.

(Smith et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mask^6.3 is an enhancer of visible phenotype of csw^CS.hs.2sev

(Smith et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

mask^6.3 is an enhancer of ommatidium phenotype of csw^CS.hs.2sev

(Smith et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the csw^CS.hs.2sev rough eye phenotype.

(Smith et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mask^6.3

(Sarkar et al., 2025, Sansores-Garcia et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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