FlyBase Allele Report: Dmel\csw[CS.hs.2sev]

General Information

Symbol

Dmel\csw^CS.hs.2sev

Species

D. melanogaster

Name

FlyBase ID

FBal0051685

Feature type

allele

Associated gene

Dmel\csw

Associated Insertion(s)

Carried in Construct

P{sevhs-csw^CS}

Key Links

Transgenic product class

dominant_negative_variant

(Jarvis et al., 2006)

missense_variant

(Herbst et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Jarvis et al., 2006)

missense_variant

(Herbst et al., 1996)

Mutagen

in vitro construct

(Allard et al., 1998, Herbst et al., 1996)

Progenitor genotype

Carried in construct

P{sevhs-csw^CS}

Cytology

Description

sev enhancer elements and an Hsp70 promoter drive expression of a mutated form of csw which contains the amino acid replacement C583S.

(Herbst et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

csw

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Smith et al., 2002)

visible

(Smith et al., 2002, Herbst et al., 1996)

visible | dominant

(Allard et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies that express csw^CS.hs.2sev in the developing eye have fewer outer photoreceptors per ommatidium (on average 5) than wild-type flies (6 per ommatidium).

(Jarvis et al., 2006)

Expression of csw^CS.hs.2sev results in a rough eye phenotype, with an average of 5.5 outer photoreceptors per ommatidium. 93% of ommatidia have an R7 photoreceptor cell. csw^CS.hs.2sev third larval instar eye discs show an increase in the number of apoptotic cells posterior to the morphogenetic furrow. There is also a zone of apoptotic cells anterior to the morphogenetic furrow, which is not seen in wild-type discs.

(Smith et al., 2002)

Flies expressing csw^CS.hs.2sev in a wild-type background show disruption of the normal ommatidial array due to loss of photoreceptor cells, including R3, R4 and R7 (approximately 45% of ommatidia contain an R7 cell).

(Allard et al., 1998)

Flies have mildly roughened eyes due to frequent absence of photoreceptors R3, R4 and R7.

(Herbst et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^5.8

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^6.3

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^7.13

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^7.29

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^7.2

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^8.7

(Smith et al., 2002)

csw^CS.hs.2sev has increased cell death phenotype, enhanceable by mask[+]/mask^10.22

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask[+]/mask^10.22

(Smith et al., 2002)

csw^CS.hs.2sev has visible phenotype, enhanceable by mask^10.18

(Smith et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^10.18

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^5.8

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^6.3

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^7.13

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^7.29

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^7.2

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask^8.7

(Smith et al., 2002)

csw^CS.hs.2sev has eye disc phenotype, enhanceable by mask[+]/mask^10.22

(Smith et al., 2002)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by mask[+]/mask^10.22

(Smith et al., 2002)

csw^CS.hs.2sev has eye phenotype, enhanceable by dos^1.46

(Herbst et al., 1999)

csw^CS.hs.2sev has ommatidium phenotype, enhanceable by dos^1.46

(Herbst et al., 1999)

csw^CS.hs.2sev has phenotype, enhanceable by dos^1.46

(Herbst et al., 1996)

csw^CS.hs.2sev has phenotype, enhanceable by dos^2.42

(Herbst et al., 1996)

csw^CS.hs.2sev has phenotype, enhanceable by dos^unspecified

(Herbst et al., 1996)

Suppressed by

Statement

Reference

csw^CS.hs.2sev has phenotype, suppressible by dos^YY.hs.2sev

(Herbst et al., 1999)

NOT suppressed by

Statement

Reference

csw^CS.hs.2sev has outer photoreceptor cell phenotype, non-suppressible by sty[+]/sty^Δ5

(Jarvis et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced outer photoreceptor cell phenotype of eyes expressing csw^CS.hs.2sev is not suppressed when eyes have a sty^Δ5/+ background.

(Jarvis et al., 2006)

The number of apoptotic cells in csw^CS.hs.2sev third larval instar eye discs is increased, both anterior and posterior to the morphogenetic furrow if the flies are also carrying one copy of mask^10.22.

(Smith et al., 2002)

The rough eye phenotype seen in csw^CS.hs.2sev flies is enhanced by the addition of dos^1.46. The addition of dos^hs.2sev.cHa or dos^YY.hs.2sev strongly suppresses this phenotype.

(Herbst et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

csw^CS.hs.2sev partially rescues csw^{G547E.hs.2sev}

(Allard et al., 1998)

Fails to rescue

csw^CS.hs.2sev fails to rescue csw^13-87

(Allard et al., 1998)

csw^CS.hs.2sev fails to rescue csw⁶

(Allard et al., 1998)

Comments

Does not rescue the zygotic lethality of csw^13-87/Y or csw⁶/Y males.

(Allard et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CSW^CS

(Herbst et al., 1999)

Csw^CS

(Feng, 1999)

csw^CS.hs.2sev

csw^CS.hs.sev

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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