FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\psh5
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General Information
Symbol
Dmel\psh5
Species
D. melanogaster
Name
FlyBase ID
FBal0138173
Feature type
allele
Associated gene
Dmel\psh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ligoxygakis et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: G340E. Nucleotide substitution: G?A.

(Ligoxygakis et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,484,812..18,484,812 [-]
Nucleotide change:

G18484812A

Reported nucleotide change:

G?A

Amino acid change:

G341E | psh-PA

Reported amino acid change:

G340E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ligoxygakis et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      psh5 flies are highly susceptible to fungal infection (B.bassiana), but show a wild-type pattern of survival after infection with Gram-positive bacteria (E.faecalis previously known as 'Streptococcus faecalis') and are resistant to Gram-negative bacterial infection.

      (Ligoxygakis et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      psh5 is a suppressor of short lived phenotype of nec1/nec2

      (Ligoxygakis et al., 2002)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      psh5 is a non-suppressor of adult tracheal system phenotype of Scer\GAL4btl.PS, Spn77BaRNAi.WIZ.UAS

      (Tang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The melanisation of the adult tracheal system caused by expression of Spn77BadsRNA.WIZ.Scer\UAS under the control of Scer\GAL4btl.PS is not suppressed by psh5.

      (Tang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a suppressor of the nec mutant phenotype.

      (Ligoxygakis et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      psh5
      (Tang et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)