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General Information
Symbol
Dmel\psh4
Species
D. melanogaster
Name
FlyBase ID
FBal0138174
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C18485391T

Reported nucleotide change:

C?T

Amino acid change:

H187Y | psh-PA

Reported amino acid change:

H187Y

Comment:

Same mutation as psh1

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: H187Y. Nucleotide substitution: C?T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

psh4 mutants show significantly increased mortality upon infection with the Gram-positive bacterium Enterococcus faecalis (wild type or the protease-deficient strain TX5128), with the Gram-positive bacterium Staphylococcus aureus or with the entomopathogenic fungus Beauveria bassiana, but not with the Gram-positive bacterium Enterococcus faecium, as compared to controls.

psh4 mutant flies show comparable levels of mortality to wild type in response to mild wounding in 7-8 day old adults.

Mutant flies show reduced survival compared to wild-type controls after natural infection with B. bassiana.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

psh4 is a suppressor of short lived phenotype of nec1/nec2

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Flies doubly mutant for grassHerrade and psh4 are more susceptible to infection by both fungi and Gram-positive bacteria than any of the single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a suppressor of the nec mutant phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)