FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\psh4
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General Information
Symbol
Dmel\psh4
Species
D. melanogaster
Name
FlyBase ID
FBal0138174
Feature type
allele
Associated gene
Dmel\psh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ligoxygakis et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: H187Y. Nucleotide substitution: C?T.

(Ligoxygakis et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,485,391..18,485,391 [-]
Nucleotide change:

C18485391T

Reported nucleotide change:

C?T

Amino acid change:

H187Y | psh-PA

Reported amino acid change:

H187Y

Comment:

Same mutation as psh1

(Ligoxygakis et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      psh4 mutants show significantly increased mortality upon infection with the Gram-positive bacterium Enterococcus faecalis (wild type or the protease-deficient strain TX5128), with the Gram-positive bacterium Staphylococcus aureus or with the entomopathogenic fungus Beauveria bassiana, but not with the Gram-positive bacterium Enterococcus faecium, as compared to controls.

      (Patrnogic and Leclerc, 2017)

      psh4 mutant flies show comparable levels of mortality to wild type in response to mild wounding in 7-8 day old adults.

      (Nam et al., 2012)

      Mutant flies show reduced survival compared to wild-type controls after natural infection with B. bassiana.

      (Fullaondo et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      psh4 is an enhancer of abnormal immune response | recessive phenotype of grassHerrade

      (El Chamy et al., 2008)
      Suppressor of
      Statement
      Reference

      psh4 is a suppressor of short lived phenotype of nec1/nec2

      (Ligoxygakis et al., 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies doubly mutant for grassHerrade and psh4 are more susceptible to infection by both fungi and Gram-positive bacteria than any of the single mutants.

      (El Chamy et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a suppressor of the nec mutant phenotype.

      (Ligoxygakis et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Psh4
      (Nam et al., 2012, El Chamy et al., 2008)
      psh4
      (Patrnogic and Leclerc, 2017, Fullaondo et al., 2011, Gottar et al., 2006, Jang et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)