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Citation
Patrnogic, J., Leclerc, V. (2017). The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria.  PLoS ONE 12(12): e0188339.
FlyBase ID
FBrf0237463
Publication Type
Research paper
Abstract

In Drosophila, recognition of pathogens such as Gram-positive bacteria and fungi triggers the activation of proteolytic cascades and the subsequent activation of the Toll pathway. This response can be achieved by either detection of pathogen associated molecular patterns or by sensing microbial proteolytic activities ("danger signals"). Previous data suggested that certain serine protease homologs (serine protease folds that lack an active catalytic triad) could be involved in the pathway. We generated a null mutant of the serine protease homolog spheroide (sphe). These mutant flies are susceptible to Enterococcus faecalis infection and unable to fully activate the Toll pathway. Sphe is required to activate the Toll pathway after challenge with pathogenic Gram-Positive bacteria. Sphe functions in the danger signal pathway, downstream or at the level of Persephone.

PubMed ID
PubMed Central ID
PMC5718610 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for sphe deletions.
Leclerc, 2019.1.18, Location data for sphe deletions. [FBrf0241239]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Aberrations (1)
    Alleles (13)
    Gene Groups (1)
    Genes (11)
    Human Disease Models (1)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (8)