FlyBase Allele Report: Dmel\grass[Herrade]

General Information

Symbol

Dmel\grass^Herrade

Species

D. melanogaster

Name

FlyBase ID

FBal0240606

Feature type

allele

Associated gene

Dmel\grass

Associated Insertion(s)

Carried in Construct

Also Known As

grass^hrd

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(El Chamy et al., 2008)

Progenitor genotype

P{XP}Men-b^d11068

(El Chamy et al., 2008)

Men-b^d11068

(Buchon et al., 2009)

Cytology

Description

A small deletion resulting from the imprecise excision of P{XP}Mdh^d11068, extending from the progenitor insertion site to nucleotide 735 in the grass transcript, which deletes the first 101 amino acids of the open reading frame.

(El Chamy et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:27,157,486..27,158,807 [+]

Comment:

Deletion resulting from the imprecise excision of P{XP}Men-b^d11068. The deletion extends from the insertion site into grass, removing the first 101 amino acids of the protein.

(El Chamy et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Fullaondo et al., 2011)

abnormal immune response | recessive

(El Chamy et al., 2008)

viable

(El Chamy et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant flies show reduced survival compared to wild-type controls after natural infection with B. bassiana.

(Fullaondo et al., 2011)

grass^Herrade mutant flies are highly susceptible to infection by Gram-positive bacteria and they are deficient in their response to infection by the fungus Beauveria bassiana and the yeast Candida albicans.

(El Chamy et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

grass^Herrade has abnormal immune response | recessive phenotype, enhanceable by psh⁴

(El Chamy et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Flies doubly mutant for grass^Herrade and psh⁴ are more susceptible to infection by both fungi and Gram-positive bacteria than any of the single mutants.

(El Chamy et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

67099

P{Dipt2.2-lacZ}1, P{Drs-GFP.JM804}1, w^*; grass^Herrade/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Grass^Herrade

(Dudzic et al., 2019, Buchon et al., 2009)

Grass^hrd

(Issa et al., 2018)

grass^Her

(Alpar et al., 2018)

grass^Herrade

(Fullaondo et al., 2011, El Chamy et al., 2008)

grass^hrd

(Patrnogic and Leclerc, 2017)

hrd

(El Chamy et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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