FlyBase Allele Report: Dmel\Nedd8[EP2063]

General Information

Symbol

Dmel\Nedd8^EP2063

Species

D. melanogaster

Name

FlyBase ID

FBal0141631

Feature type

allele

Associated gene

Dmel\Nedd8

Associated Insertion(s)

P{EP}Nedd8^EP2063

Carried in Construct

Also Known As

EP(2)2063

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Chan et al., 2008)

Mutagen

P-element activity

(Ou et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{EP}Nedd8^EP2063

Cytology

Description

P{EP} insertion 91bp upstream of the Nedd8 translation start site.

(Ou et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:18,951,813..18,951,813 [-]

(Maybeck and Röper, 2009, Ou et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage (with Nedd8^AN015)

(Chan et al., 2008)

lethal - all die before end of pupal stage (with Nedd8^AN024)

(Chan et al., 2008)

some die during pupal stage (with Nedd8^AN015)

(Chan et al., 2008)

some die during pupal stage (with Nedd8^AN024)

(Chan et al., 2008)

Phenotype Manifest In

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

(Maybeck and Röper, 2009)

Detailed Description

Statement

Reference

Expression via Scer\GAL4^fkh.PH results in a weakly penetrant positioning ('butterfly') phenotype in the embryonic salivary gland.

(Maybeck and Röper, 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nedd8^EP2063/Nedd8^AN015 has lethal phenotype, suppressible | partially by Den1^EX9/Den1[+]

(Chan et al., 2008)

Nedd8^EP2063/Nedd8^AN024 has lethal phenotype, suppressible | partially by Den1^EX9/Den1[+]

(Chan et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

122047

w¹¹¹⁸; P{EP}Nedd8^EP2063

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nedd8^EP(2)2063

(Ou et al., 2002)

Nedd8^EP2063

(Chan et al., 2008)

Nedd8^P2063

(Chan et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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