FlyBase Allele Report: Dmel\CSN4[null]

General Information

Symbol

Dmel\CSN4^null

Species

D. melanogaster

Name

FlyBase ID

FBal0141865

Feature type

allele

Associated gene

Dmel\CSN4

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Oron et al., 2002)

Progenitor genotype

CSN4^k08018

(Oron et al., 2002)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in a deletion of CSN4 nucleotides -375 to +55 (relative to the first nucleotide of the start codon).

(Oron et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cephalopharyngeal skeleton

(Oron et al., 2002)

ovary | germline clone

(Oron et al., 2002)

trichogen cell | somatic clone | increased number

(Mummery-Widmer et al., 2009)

wing vein | somatic clone

(Suisse et al., 2017)

Detailed Description

Statement

Reference

Adult flies carrying CSN4^null mutant clones in the wings display extra wing veins.

(Suisse et al., 2017)

Homozygous clones in the thorax result in hair cell duplication phenotypes.

(Mummery-Widmer et al., 2009)

Homozygous third instar larvae are much smaller than their control siblings. Homozygous larvae show moulting defects; the second instar mouth parts fail to detach from the newly formed third instar mouth hooks, giving a double mouth hook phenotype. Some of these larvae also show defects in ecdysis as the shed second instar cuticle also remains attached at the head. These defects are seen in about 20% of mutant second to third instar larvae. Embryos are not recovered from females containing homozygous germline clones. Oogenesis is arrested at stage 6 in these females. Homozygous larvae are sensitive to methyl methanesulfonate compared to controls.

(Oron et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

CSN4[+]/CSN4^null is a non-suppressor of abnormal size phenotype of Scer\GAL4^Bx-MS1096, Trc8^UAS.Tag:MYC

(Gemmill et al., 2005)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

CSN4[+]/CSN4^null is a non-suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, Trc8^UAS.Tag:MYC

(Gemmill et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CSN4^null2.2

(Gemmill et al., 2005)

CSN4^null

(Suisse et al., 2017, Mummery-Widmer et al., 2009, Wu et al., 2005)

csn4^null

(Oron et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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