FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wunEMS4
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General Information
Symbol
Dmel\wunEMS4
Species
D. melanogaster
Name
FlyBase ID
FBal0143104
Feature type
allele
Associated gene
Dmel\wun
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kozopas, 2003.3)
Progenitor genotype
Cytology
Description

Amino acid replacement: R238C.

(Renault, 2013.10.7)

C to T nucleotide change resulting in a R238C amino acid change.

(Renault, 2013.10.7)

Nucleotide substitution: C?T.

(Renault, 2013.10.7)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,402,486..9,402,486 [-]
Nucleotide change:

C9402486T

Reported nucleotide change:

C?T

Amino acid change:

R238C | wun-PA; R317C | wun-PB; R317C | wun-PC

Reported amino acid change:

R238C

(Renault, 2013.10.7)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Duchenne muscular dystrophy
      modeled by DysRNAi.C.UAS
      (Pantoja et al., 2013)
      modeled by DysRNAi.NH2.UAS
      (Pantoja et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      wun[+]/wunEMS4 is a suppressor of indirect flight muscle cell phenotype of DysRNAi.C.UAS, Scer\GAL4Tub.PU

      (Pantoja et al., 2013)

      wun[+]/wunEMS4 is a suppressor of myofibril phenotype of DysRNAi.C.UAS, Scer\GAL4Tub.PU

      (Pantoja et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of wunEMS4 suppresses the gross defects in indirect flight muscle morphology seen when DysdsRNA.C.Scer\UAS is expressed under the control of Scer\GAL4tub.PU. The reduction in activity levels is also suppressed.

      One copy of wunEMS4 suppresses the defects in indirect flight muscle indirect flight muscle myofibril integrity seen in Df(3R)Exel6184 mutant flies.

      One copy of wunEMS4 suppresses the reduction in activity levels seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

      (Pantoja et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Arose in: screen described in FBrf0102352.

      (Kozopas, 2003.3)
      Comments
      Comments

      Fails to complement: wunk16806.

      (Kozopas, 2003.3)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wun4
      (Pantoja et al., 2013)
      wunEMS4
      (Pantoja et al., 2013, Renault, 2013.10.7)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)