FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fruMB.UAS.cSa
Open Close
General Information
Symbol
Dmel\fruMB.UAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0144289
Feature type
allele
Associated gene
Dmel\fru
Associated Insertion(s)
Carried in Construct
P{UAS-fru.MB.S}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Song et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-fru.MB.S}
Cytology
Description

UASt regulatory sequences drive expression of fru consisting of sequences encoding the 101 male specific amino terminus and the BTB domain derived from the fru male cDNA nos. 5-19 fused to the "B" 3' end (derived from fru cDNA no. 25).

(Song et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fru
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately 15% of wild-type females expressing fruMB.Scer\UAS.cSa under the control of Scer\GAL4fru.16 develop on average three ectopic `male' serotonergic neurons, sending projections into the abdominal nerve trunk. Ectopic serotonergic terminals innervated the female internal reproductive organs, mostly the calyx of the ovaries but also, more rarely, the uterus and the base of the spermathecae. These serotonergic terminals are never present in virgin or fertilised wild-type females. The ectopic serotonergic neurons and their associated terminalia are analogous to those innervating the male reproductive organs.

      (Billeter et al., 2006)

      The Fas2-positive and BP102-positive axon tracts in the central nervous system are defective in virtually all fruw12/frusat15 embryos which are expressing fruMB.Scer\UAS.cSa under the control of Scer\GAL4sca-537.4.

      (Song et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      fruMB.UAS.cSa/Scer\GAL4fru.16 fails to rescue fru3/fruΔC

      (Billeter et al., 2006)

      fruMB.UAS.cSa/Scer\GAL4fru.16 fails to rescue fru3

      (Billeter et al., 2006)
      Comments

      Expression of fruMB.Scer\UAS.cSa, under the control of Scer\GAL4fru.16 in a fru3/fru3 background does not restore male fertility.

      Expression of fruMB.Scer\UAS.cSa under the control of Scer\GAL4fru.16 fails to rescue fertility levels in fru3/fruΔC mutants.

      Expression of fruMB.Scer\UAS.cSa under the control of Scer\GAL4fru.16, in fru3 homozygotes and fru3/fruΔC transheterozygotes fails to rescue the formation of the muscle of Lawrence in the male and fails to induce formation of muscle of Lawrence-like features and neuromuscular junctions in the female.

      Expression of fruMB.Scer\UAS.cSa under the control of Scer\GAL4fru.16 in fruΔC/fru3 mutants induces differentiation of neurons in the dorsal serotonergic abdominal giant neurons, with up to five neurons (half the wild-type number) developing per animal. Rescue in the ventral serotonergic abdominal giant neurons is not observed.

      (Billeter et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fruMB.Scer\UAS.cSa
      fruMB.UAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)