FlyBase Allele Report: Dmel\CSN5[quo-3]

General Information

Symbol

Dmel\CSN5^quo-3

Species

D. melanogaster

Name

FlyBase ID

FBal0145141

Feature type

allele

Associated gene

Dmel\CSN5

Associated Insertion(s)

Carried in Construct

Also Known As

CSN5³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Suh et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: T99I.

(Oron et al., 2002)

A missense mutation.

(Suh et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:16,470,530..16,470,530 [+]

Nucleotide change:

C16470530T

Amino acid change:

T100I | CSN5-PA; T100I | CSN5-PB

Reported amino acid change:

T99I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Oron et al., 2002, Suh et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size (with CSN5^null)

(Gemmill et al., 2005)

lethal (with CSN5^quo-2)

(Suh et al., 2002)

lethal | recessive

(Gemmill et al., 2005)

lethal - all die before end of pupal stage | recessive

(Suh et al., 2002)

partially lethal - majority die (with CSN5^null)

(Gemmill et al., 2005)

some die during immature adult stage | recessive (with CSN5^quo-2)

(Suh et al., 2002)

some die during pupal stage | recessive

(Suh et al., 2002)

Phenotype Manifest In

wing (with CSN5^null)

(Gemmill et al., 2005)

Detailed Description

Statement

Reference

About half of CSN5^quo-3/CSN5^null animals emerge as adults. These escapers are overall smaller than wild type and have droopy wings.

(Gemmill et al., 2005)

CSN5^quo-2/CSN5^quo-3 animals sometimes survive to adulthood. These animals are morphologically normal, but die a few days after eclosion.

(Suh et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

CSN5[+]/CSN5^quo-3 is a suppressor of abnormal size phenotype of Scer\GAL4^Bx-MS1096, Trc8^UAS.Tag:MYC

(Gemmill et al., 2005)

CSN5[+]/CSN5^quo-3 is a suppressor | partially of abnormal size phenotype of Scer\GAL4^en.PU, Trc8^UAS.Tag:MYC

(Gemmill et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

CSN5[+]/CSN5^quo-3 is a suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, Trc8^UAS.Tag:MYC

(Gemmill et al., 2005)

CSN5[+]/CSN5^quo-3 is a suppressor | partially of wing phenotype of Scer\GAL4^en.PU, Trc8^UAS.Tag:MYC

(Gemmill et al., 2005)

CSN5[+]/CSN5^quo-3 is a suppressor of nurse cell phenotype of CycE^JP

(Doronkin et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

CSN5^quo-3/+ restores normal appearing growth to Scer\GAL4^Bx-MS1096, Trc8^{Scer\UAS.T:Hsap\MYC} female wings and substantially increases wing size in male wings.

CSN5^quo-3/+ partially restores the anterior/posterior size ratio of Scer\GAL4^en.PU, Trc8^{Scer\UAS.T:Hsap\MYC} wings towards wild type.

(Gemmill et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Sanchez-Herrero

(Suh et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CSN5³

(Gemmill et al., 2005, Suh et al., 2002)

CSN5^quo-3

csn5³

(Oron et al., 2002)

quo³

(Suh et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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