FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CSN5quo-2
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General Information
Symbol
Dmel\CSN5quo-2
Species
D. melanogaster
Name
FlyBase ID
FBal0145142
Feature type
allele
Associated gene
Dmel\CSN5
Associated Insertion(s)
Carried in Construct
Also Known As
CSN52
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Suh et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: G146D.

(Gemmill et al., 2005, Suh et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:16,470,668..16,470,668 [+]
Nucleotide change:

G16470668A

Amino acid change:

G146D | CSN5-PA; G146D | CSN5-PB

Reported amino acid change:

G146D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Gemmill et al., 2005, Suh et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oogenesis is severely defective in CSN5quo-2 mutants.

      (Doronkin et al., 2003)

      CSN5quo-2/CSN5quo-3 animals sometimes survive to adulthood. These animals are morphologically normal, but die a few days after eclosion. In mutant larvae many R2-R5 axons fail to terminate in the lamina (as seen in wild-type) and instead, project into the medulla. This phenotype is not due to a transformation of R2-R5 into R7 and/or R8.

      (Suh et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      CSN5quo-2/CSN5[+] is a non-suppressor of abnormal size phenotype of Scer\GAL4Bx-MS1096, Trc8UAS.Tag:MYC

      (Gemmill et al., 2005)
      Other
      Statement
      Reference

      CSN5quo-2/CSN5[+], Scer\GAL4en.PU, Trc8UAS.Tag:MYC has lethal phenotype

      (Gemmill et al., 2005)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      CSN5quo-2/CSN5[+] is a suppressor of nurse cell phenotype of CycEJP

      (Doronkin et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      CSN5quo-2/CSN5[+] is a non-suppressor of wing phenotype of Scer\GAL4Bx-MS1096, Trc8UAS.Tag:MYC

      (Gemmill et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Sanchez-Herrero

      (Suh et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CSN52
      (Gemmill et al., 2005, Suh et al., 2002)
      CSN5quo-2
      quo2
      (Suh et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)