FlyBase Allele Report: Dmel\chb[5]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\chb⁵

General Information

Symbol

Dmel\chb⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0147232

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

orbit⁵

Key Links

Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Mathe et al., 2003)

Mutagen

P-element activity

(Mathe et al., 2003)

Progenitor genotype

Associated Insertion(s)

Cytology

Description

P{lacW} insertion 609bp upstream of the first ATG codon of the chb open reading frame.

(Mathe et al., 2003)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,177,524..21,177,524

(Mathe et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | oogenesis (with chb⁶)

(Mathe et al., 2003)

decreased cell number | oogenesis (with chb⁶)

(Mathe et al., 2003)

female sterile (with chb⁶)

(Mathe et al., 2003)

female sterile (with chb^S068607)

(Mathe et al., 2003)

female sterile | recessive

(Mathe et al., 2003)

lethal | larval stage (with Df(3L)Pc-MK)

(Mathe et al., 2003)

lethal | pupal stage (with Df(3L)Pc-MK)

(Mathe et al., 2003)

lethal - all die before end of P-stage | recessive

(Mathe et al., 2003)

male sterile (with chb⁶)

(Mathe et al., 2003)

male sterile (with chb^S068607)

(Mathe et al., 2003)

male sterile | recessive

(Mathe et al., 2003)

some die during pharate adult stage | recessive

(Mathe et al., 2003)

viable (with chb⁶)

(Mathe et al., 2003)

Phenotype Manifest In

(Mathe et al., 2003)

egg chamber (with chb⁶)

(Mathe et al., 2003)

(Mathe et al., 2003)

ovary (with chb⁶)

(Mathe et al., 2003)

(Inoue et al., 2004)

(Inoue et al., 2004)

Detailed Description

Statement

Reference

chb⁵ testes are defect ridden and lack spermatids.

(Inoue et al., 2004)

Most homozygotes die as pharate adults, but 1-5% reach adulthood. These male and female escapers are sterile. Homozygous adults die shortly after eclosion and females do not lay eggs. Homozygous and chb⁵/chb⁶ females have small ovaries and only a few egg chambers are found in about one-fifth of the mutant ovaries. Oogenesis never proceeds beyond mid-oogenesis.

(Mathe et al., 2003)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

chb⁵ is rescued by chb^+t14

(Mathe et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

chb⁵

orbit⁵

(Inoue et al., 2004, Mathe et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections