FlyBase Allele Report: Dmel\sqz[ie]

General Information

Symbol

Dmel\sqz^ie

Species

D. melanogaster

Name

FlyBase ID

FBal0150237

Feature type

allele

Associated gene

Dmel\sqz

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Allan et al., 2003)

Mutagen

P-element activity

(Allan et al., 2003)

Progenitor genotype

sqz^GAL4

(Allan et al., 2003)

Cytology

Description

Imprecise excision of the P{GawB} element from sqz^GAL4 results in removal of part of the P-element and the second and third exon.

(Allan et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Tsuji et al., 2008)

abnormal neuroanatomy | somatic clone

(Komiyama and Luo, 2007)

lethal - all die before end of larval stage (with Df(3R)Delta-KX23)

(Allan et al., 2003)

some die during larval stage (with Df(3R)Delta-KX23)

(Allan et al., 2003)

Phenotype Manifest In

adult antennal lobe projection neuron DM5 lPN | somatic clone

(Komiyama and Luo, 2007)

larval EL neuron | embryonic stage | increased number

(Tsuji et al., 2008)

neuroblast NB3-3 | embryonic stage

(Tsuji et al., 2008)

Detailed Description

Statement

Reference

The number of SE2 neurons is normal in sqz^ie mutant animals.

There are no SELK neurons observed in sqz^ie mutant animals.

(Losada-Pérez et al., 2010)

Mutants show a delay in thoracic neuroblast 3-3 (NB3-3T) entering quiescence, and a corresponding increase in the number of EL neurons.

(Tsuji et al., 2008)

Targeting of DM5 lPN to the DM5 glomerulus fails in sqz^ie homozygous somatic clones.

(Komiyama and Luo, 2007)

Penetrance is 100% for larval lethality in Df(3R)Dl-KX23/sqz^ie animals.

(Allan et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36497

w^*; P{UAS-sqz.A}7-3/CyO; P{neoFRT}82B sqz^ie/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sqz^-

(Komiyama and Luo, 2007)

sqz^IE

(Eade et al., 2012)

sqz^ie

(Stratmann et al., 2016, Berndt et al., 2015, Bivik et al., 2015, Herrero et al., 2014, Losada-Pérez et al., 2013, Benito-Sipos et al., 2011, Benito-Sipos et al., 2010, Losada-Pérez et al., 2010, Baumgardt et al., 2009, Tsuji et al., 2008, Baumgardt et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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