FlyBase Allele Report: Dmel\pk[pk.sev]

General Information

Symbol

Dmel\pk^pk.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0150302

Feature type

allele

Associated gene

Dmel\pk

Associated Insertion(s)

Carried in Construct

P{sev-pk^pk}

Key Links

Transgenic product class

wild_type

(Jenny et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Jenny et al., 2003)

Mutagen

in vitro construct

(Jenny, 2003, Jenny et al., 2003)

Progenitor genotype

Carried in construct

P{sev-pk^pk}

Cytology

Description

The sev promoter drives expression of the pk[pk] isoform of pk.

(Jenny et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Jenny et al., 2003)

Phenotype Manifest In

ommatidium

(Jenny et al., 2003)

Detailed Description

Statement

Reference

Mutant animals exhibit typical planar cell polarity defects in the eye: symmetric ommatidia and chirality and rotation defects, with about 56% (+-8.4) of ommatidia exhibiting abnormal polarity.

(Jenny et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

pk^pk.sev has abnormal cell polarity phenotype, enhanceable by Vang^stbm-6

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, enhanceable by Vang^x

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, enhanceable by dsh¹

(Jenny et al., 2003)

NOT Enhanced by

Statement

Reference

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by dgo³⁰⁸

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by dgo³⁸⁰

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by fz²³

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by stan^E45

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by stan^E59

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by Delta^RevF10

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-enhanceable by N^55e11

(Jenny et al., 2003)

Suppressed by

Statement

Reference

pk^pk.sev has abnormal cell polarity phenotype, suppressible by dsh³

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, suppressible by fz³⁰

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, suppressible by Rok¹

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, suppressible by Rho1^72O

(Jenny et al., 2003)

NOT suppressed by

Statement

Reference

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by Delta^RevF10

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by N^55e11

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by dgo³⁰⁸

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by dgo³⁸⁰

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by fz²³

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by stan^E45

(Jenny et al., 2003)

pk^pk.sev has abnormal cell polarity phenotype, non-suppressible by stan^E59

(Jenny et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

pk^pk.sev has ommatidium phenotype, enhanceable by Vang^stbm-6

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, enhanceable by Vang^x

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, enhanceable by dsh¹

(Jenny et al., 2003)

NOT Enhanced by

Statement

Reference

pk^pk.sev has ommatidium phenotype, non-enhanceable by dgo³⁰⁸

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-enhanceable by dgo³⁸⁰

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-enhanceable by fz²³

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-enhanceable by stan^E45

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-enhanceable by stan^E59

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-enhanceable by Delta^RevF10

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-enhanceable by N^55e11

(Jenny et al., 2003)

Suppressed by

Statement

Reference

pk^pk.sev has ommatidium phenotype, suppressible by Rho1^72O

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, suppressible by dsh³

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, suppressible by fz³⁰

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, suppressible by Rok¹

(Jenny et al., 2003)

NOT suppressed by

Statement

Reference

pk^pk.sev has ommatidium phenotype, non-suppressible by dgo³⁸⁰

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-suppressible by fz²³

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-suppressible by stan^E45

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-suppressible by stan^E59

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-suppressible by Delta^RevF10

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-suppressible by N^55e11

(Jenny et al., 2003)

pk^pk.sev has ommatidium phenotype, non-suppressible by dgo³⁰⁸

(Jenny et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Rho1^72O to pk^pk.sev animals partially suppresses its ommatidial polarity phenotype, with about 34.5% of ommatidia exhibiting abnormal polarity. The addition of Vang^stbm-6 to pk^pk.sev animals enhances its ommatidial polarity phenotype, with about 76.2% of ommatidia exhibiting abnormal polarity. The addition of Vang^x to pk^pk.sev animals enhances its ommatidial polarity phenotype, with about 77.5% of ommatidia exhibiting abnormal polarity. The addition of dsh¹ to pk^pk.sev animals enhances its ommatidial polarity phenotype, with about 63.2% of ommatidia exhibiting abnormal polarity. The addition of dsh³ to pk^pk.sev animals partially suppresses its ommatidial polarity phenotype, with about 44.4% of ommatidia exhibiting abnormal polarity. The addition of fz²³ to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 47.8 (+-2.7)% of ommatidia exhibiting abnormal polarity. The addition of fz³⁰ to pk^pk.sev animals partially suppresses its ommatidial polarity phenotype, with about 34.7% of ommatidia exhibiting abnormal polarity. The addition of stan^E59 to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 58.9 (+-2.7)% of ommatidia exhibiting abnormal polarity. The addition of stan^E45 to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 52.4 (+-9.4)% of ommatidia exhibiting abnormal polarity. The addition of dgo³⁰⁸ to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 58.4 (+-5.9)% of ommatidia exhibiting abnormal polarity. The addition of dgo³⁸⁰ to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 62.0 (+-7.8)% of ommatidia exhibiting abnormal polarity. The addition of N^55e11 to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 61.5 (+-14.4)% of ommatidia exhibiting abnormal polarity. The addition of Dl^RevF10 to pk^pk.sev animals has no significant effect on ommatidial polarity phenotype, with about 49.9 (+-1.3)% of ommatidia exhibiting abnormal polarity. The addition of rok¹ to pk^pk.sev animals partially suppresses its ommatidial polarity phenotype, with about 38.1% of ommatidia exhibiting abnormal polarity.

(Jenny et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pk^pk.sev

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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