FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nipped-ANC186
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General Information
Symbol
Dmel\Nipped-ANC186
Species
D. melanogaster
Name
FlyBase ID
FBal0150723
Feature type
allele
Associated gene
Dmel\Nipped-A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Myster et al., 2004, Myster and Peifer, 2003.9.11)
Progenitor genotype
Cytology
Description

Nucleotide numbering based on a hybrid sequence with the first nucleotide of the most 5' RACE product from an isogenic cn bw chromosome defined as nucleotide 1. Amino acid numbering based on residues encoded by the major Nipped-A transcript identified by authors.

(Gause et al., 2006)

Nucleotide substitution: T52327A.

(Gause et al., 2006)

Amino acid replacement: V1191D.

(Gause et al., 2006)

Amino acid replacement: V885D. Nucleotide substitution: A?T.

(Myster et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:5,198,722..5,198,722 [-]
Nucleotide change:

T5198722A

Reported nucleotide change:

A?T

Reported nucleotide change:

T52327A

Amino acid change:

V1191D | Nipped-A-PE; V1191D | Nipped-A-PF

Reported amino acid change:

V885D

Reported amino acid change:

V1191D

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Based on sequence from Figure 7 of FBrf0174713.

(Gause et al., 2006, Myster et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neurodegenerative disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Zhang et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18[o]C, 14.9% of pupae from a cross of Nipped-ANC186 x Df(2R)Nipped-E43 are of the Nipped-ANC186/Df(2R)Nipped-E43 genotype. At 25[o]C, only 2.3% have this genotype.

      At 18[o]C, 3.7% of pupae from a cross of Nipped-ANC186 x Nipped-ANC106 are of the Nipped-ANC186/Nipped-ANC106 genotype.

      At 18[o]C, 4.6% of pupae from a cross of Nipped-ANC186 x Nipped-ANC194 are of the Nipped-ANC186/Nipped-ANC194 genotype.

      (Gause et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Nipped-A[+]/Nipped-ANC186 is an enhancer of visible | progressive phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4GMR.PU

      (Zhang et al., 2010)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Nipped-A[+]/Nipped-ANC186 is an enhancer of eye | progressive phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4GMR.PU

      (Zhang et al., 2010)

      Nipped-A[+]/Nipped-ANC186 is an enhancer of wing blade phenotype of Nnd-1

      (Gause et al., 2006)
      NOT Enhancer of
      Statement
      Reference

      Nipped-A[+]/Nipped-ANC186 is a non-enhancer of wing margin phenotype of mamg2.1

      (Gause et al., 2006)
      NOT Suppressor of
      Statement
      Reference

      Nipped-A[+]/Nipped-ANC186 is a non-suppressor of wing vein L4 phenotype of NAx-E2

      (Gause et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for Nipped-ANC186 further reduces the width of Nnd-1 wings.

      (Gause et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference

      Nipped-ANC186/+ enhances the eye degeneration phenotype caused by expression of Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Zhang et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Induced on: cn1 bw1.

      (Myster and Peifer, 2003.9.11)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nipped-ANC186
      (Zhang et al., 2010, Gause et al., 2006)
      l(2)NC186
      (Myster et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)