FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\foxoEP35-147
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General Information
Symbol
Dmel\foxoEP35-147
Species
D. melanogaster
Name
FlyBase ID
FBal0151928
Feature type
allele
Associated gene
Dmel\foxo
Associated Insertion(s)
P{EP}EP35-147
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Junger et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{EP}EP35-147
Cytology
Description

Insertion of P{EP} in intron upstream of ATG-containing exon of foxo, oriented in the same direction as foxo transcription unit.

(Junger et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of foxoEP35-147 under the control of Scer\GAL4GMR.PU results in a small eye, under starvation conditions (10g/l).

      (Nowak et al., 2013)

      When expression is driven by Scer\GAL4GMR.PF the eye is reduced and the ommatidial pattern disrupted. This phenotype is exacerbated by protein deprivation. Complete starvation causes lethality.

      (Junger et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PU, foxoEP35-147 has eye | nutrition conditional phenotype, suppressible by PtenKK109278, Scer\GAL4GMR.PU

      (Nowak et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye phenotype found upon expression of foxoEP35-147 is suppressed by knockdown of Pten through expression of PtenKK109278 (with both constructs under the control of Scer\GAL4GMR.PU).

      (Nowak et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EP-147
      (Mattila et al., 2009)
      foxoEP35-147
      Name Synonyms
      Secondary FlyBase IDs
        References (5)