FlyBase Allele Report: Dmel\pros[L.UAS]

General Information

Symbol

Dmel\pros^L.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0154727

Feature type

allele

Associated gene

Dmel\pros

Associated Insertion(s)

Carried in Construct

P{UAS-pros.L}

Also Known As

UAS-pros, UAS-pros.L

Key Links

Transgenic product class

wild_type

(Cook et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Cook et al., 2003)

Mutagen

in vitro construct

(Cook et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-pros.L}

Cytology

Description

Expression of the L isoform of pros is under the control of UAS sequences.

(Cook et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

pros

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^wor.PA

(Weng et al., 2010)

decreased cell number | larval stage, with Scer\GAL4^Act.PU

(Hu et al., 2025)

decreased occurrence of cell division | larval stage, with Scer\GAL4^Act.PU

(Hu et al., 2025)

decreased size | larval stage, with Scer\GAL4^Act.PU

(Hu et al., 2025)

Phenotype Manifest In

cone cell | increased number, with Scer\GAL4^sev.EP

(Charlton-Perkins et al., 2011)

larval brain, with Scer\GAL4^Act.PU

(Hu et al., 2025)

larval neuroblast, with Scer\GAL4^wor.PA

(Weng et al., 2010)

primary pigment cell, with Scer\GAL4^sev.EP

(Charlton-Perkins et al., 2011)

rhabdomere R7 | increased number, with Scer\GAL4^sev.EP

(Charlton-Perkins et al., 2011)

Detailed Description

Statement

Reference

Compared with wild-type eyes, the ectopic expression of pros^L.Scer\UAS under the control of Scer\GAL4^sev.EP frequently leads to ommatidia with one or two extra cone cells. In addition, eyes expressing pros^L.Scer\UAS via Scer\GAL4^sev.EP with a normal complement of cone cells occasionally display an extra R7. The mutant eyes also display a decrease in the number of primary pigment cells, which is proportional to the increase in the number of R7 and cone cells.

(Charlton-Perkins et al., 2011)

Expression of pros^L.Scer\UAS induced by Scer\GAL4^wor.PA prematurely terminates neuroblast proliferation in larval brains.

(Weng et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pros^L.UAS/Scer\GAL4^GH146 is a suppressor | partially | somatic clone of abnormal neuroanatomy | somatic clone phenotype of HDAC1^12-37

(Tea et al., 2010)

pros^L.UAS/Scer\GAL4^GMR9D11 is a suppressor of abnormal neuroanatomy phenotype of erm¹

(Weng et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^sev.EP, pros^L.UAS has rhabdomere R7 | increased number phenotype, enhanceable by Scer\GAL4^sev.EP/sv^RNAi.UAS

(Charlton-Perkins et al., 2011)

Scer\GAL4^sev.EP, pros^L.UAS has rhabdomere R7 | increased number phenotype, enhanceable by sv^spa-pol

(Charlton-Perkins et al., 2011)

Suppressed by

Statement

Reference

Scer\GAL4^sev.EP, pros^L.UAS has cone cell | increased number phenotype, suppressible by Scer\GAL4^sev.EP/sv^RNAi.UAS

(Charlton-Perkins et al., 2011)

Scer\GAL4^sev.EP, pros^L.UAS has cone cell | increased number phenotype, suppressible by sv^spa-pol

(Charlton-Perkins et al., 2011)

Suppressor of

Statement

Reference

pros^L.UAS/Scer\GAL4^GH146 is a suppressor | partially | somatic clone of adult antennal lobe projection neuron DL1 adPN | somatic clone phenotype of HDAC1^12-37

(Tea et al., 2010)

pros^L.UAS/Scer\GAL4^GMR9D11 is a suppressor of larval neuroblast | ectopic | increased number phenotype of erm¹

(Weng et al., 2010)

Other

Statement

Reference

Scer\GAL4^sev.EP, pros^L.UAS, sv^RNAi.UAS has lens phenotype

(Charlton-Perkins et al., 2011)

Scer\GAL4^sev.EP, pros^L.UAS, sv^spa-pol has lens phenotype

(Charlton-Perkins et al., 2011)

Scer\GAL4^sev.EP, pros^L.UAS, sv^UAS.cKa has cone cell | increased number phenotype

(Charlton-Perkins et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of both pros^L.Scer\UAS and sv^Scer\UAS.cKa consistently converts one extra cell into a cone cell. In contrast, no change in photoreceptor cell or primary pigment cell number is observed.

Overexpression of pros^L.Scer\UAS in mutants also expressing sv^{dsRNA.Scer\UAS} under the control of Scer\GAL4^sev.EP results in a significant increase in R7 photoreceptor numbers, with up to four R7 cells per ommatidium, with an average of three. In addition, no cone cells are detected and adult lenses fail to form.

Overexpression of pros^L.Scer\UAS under the control of Scer\GAL4^sev.EP in homozygous sv^spa-pol mutant eyes results in a significant increase in R7 photoreceptor numbers, with three to four often present in individual ommatidia. In addition, no cone cells are detected and adult lenses fail to form.

(Charlton-Perkins et al., 2011)

Expression of pros^L.Scer\UAS under the control of Scer\GAL4^GH146 in DL1 projection neuron clones which are mutant for Rpd3^12-37 rescues the dendrite mistargeting defects seen in these mutant clones. In addition, the axon overbranching phenotype seen in Rpd3^12-37 clones is partially but significantly rescued.

(Tea et al., 2010)

Expression of pros^L.Scer\UAS under the control of Scer\GAL4^{CG31670.R9D11} suppresses ectopic neuroblasts and restores neuronal differentiation in erm¹ larval brains.

(Weng et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

pros^L.UAS/Scer\GAL4^GH146 rescues pros³⁸

(Tea et al., 2010)

Comments

The dendrite mistargeting and axon overbranching phenotypes seen in pros³⁸ DL1 projection neuron clones are rescued by expression in the clone of pros^L.Scer\UAS under the control of Scer\GAL4^GH146.

(Tea et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32244

P{UAS-pros.L}L3a, w^*

Notes on Origin

Discoverer

C. Doe

(Cook et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pros^L.Scer\UAS

pros^L.UAS

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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