FlyBase Allele Report: Dmel\Topors[Z4522]

General Information

Symbol

Dmel\Topors^Z4522

Species

D. melanogaster

Name

FlyBase ID

FBal0154837

Feature type

allele

Associated gene

Dmel\Topors

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Matsui et al., 2011)

Mutagen

ethyl methanesulfonate

(Wakimoto et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: E345K.

(Matsui et al., 2011)

Nucleotide substitution: G1160A.

(Matsui et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:18,974,486..18,974,486 [+]

Nucleotide change:

G18974486A

Reported nucleotide change:

G1160A

Amino acid change:

E345K | Topors-PA; E345K | Topors-PB

Reported amino acid change:

E345K

(Matsui et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | male limited (with Df(2R)Topors^AA)

(Matsui et al., 2011)

abnormal meiotic cell cycle | male limited (with Topors^f05115)

(Matsui et al., 2011)

abnormal meiotic cell cycle | male limited (with Topors^Z1837)

(Matsui et al., 2011)

abnormal meiotic cell cycle | male limited | recessive

(Matsui et al., 2011)

decreased fecundity | male

(Matsui et al., 2011)

decreased fecundity | male (with Df(2R)Topors^AA)

(Matsui et al., 2011)

decreased fecundity | male (with Topors^f05115)

(Matsui et al., 2011)

decreased fecundity | male (with Topors^Z1837)

(Matsui et al., 2011)

male fertile

(Wakimoto et al., 2004)

male semi-sterile (with Df(2R)Topors^AA)

(Matsui et al., 2011)

male semi-sterile (with Topors^f05115)

(Matsui et al., 2011)

male semi-sterile (with Topors^Z1837)

(Matsui et al., 2011)

male semi-sterile | recessive

(Matsui et al., 2011)

Phenotype Manifest In

nucleus

(Matsui et al., 2011)

spermatocyte

(Matsui et al., 2011)

Detailed Description

Statement

Reference

Homozygous and transheterozygous males, but not females, show near random segregation of all chromosomes at meiosis I, but not meiosis II, as a result of non-disjunction. Male fecundity is also greatly reduced.

Nuclear blebbing is observed in late-stage Topors^Z4522 spermatocytes, though it is variable. Blebbing is not observed in testis sheath cells, larval neuroblasts or the giant nuclei of the larval salivary gland cells.

(Matsui et al., 2011)

Homozygous males are fertile, but their progeny show paternal chromosome loss (loss rate of paternal chromosome 4 is 30%). The chromosome loss occurs during spermatogenesis and is premeiotic.

(Wakimoto et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Topors^Z4522/nbl[+] is a suppressor of wing margin phenotype of ct⁶

(Matsui et al., 2011)

Topors^Z4522/nbl[+] is a suppressor of wing margin phenotype of ct^K

(Matsui et al., 2011)

NOT Suppressor of

Statement

Reference

Topors^Z4522/nbl[+] is a non-suppressor of wing margin phenotype of ctⁿ

(Matsui et al., 2011)

Topors^Z4522/Topors^Z4522 is a non-suppressor of wing margin phenotype of ct⁶

(Matsui et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity, but not homozygosity, for Topors^Z4522 restores the wing margin of ct⁶ flies.

Heterozygosity for Topors^Z4522 only slightly suppresses the wing margin phenotype of ct^K flies.

(Matsui et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

606952

cn¹ Topors^Z4522 bw¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Topors^Z4522

dtopors^Z4522

(Matsui et al., 2011)

nbl^Z4522

(Matsui et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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