FlyBase Allele Report: Dmel\amos[1]

General Information

Symbol

Dmel\amos¹

Species

D. melanogaster

Name

FlyBase ID

FBal0155657

Feature type

allele

Associated gene

Dmel\amos

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(zur Lage et al., 2003)

Mutagen

ethyl methanesulfonate

(zur Lage et al., 2003)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C550T.

(zur Lage et al., 2003)

Amino acid replacement: Q184term.

(zur Lage et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:18,596,357..18,596,357 [-]

Nucleotide change:

C18596357T

Reported nucleotide change:

C550T

Amino acid change:

Q184term | amos-PA

Reported amino acid change:

Q184term

(zur Lage et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Df(2L)M36F-S6)

(Okumura et al., 2016)

abnormal neuroanatomy | embryonic stage

(Grillenzoni et al., 2007)

viable

(zur Lage et al., 2003)

viable (with Df(2L)M36F-S6)

(zur Lage et al., 2003)

Phenotype Manifest In

adult antennal lobe (with Df(2L)M36F-S6)

(Okumura et al., 2016)

adult antennal lobe glomerulus (with Df(2L)M36F-S6)

(Okumura et al., 2016)

embryonic antennal sense organ

(Grillenzoni et al., 2007)

macrochaeta | ectopic & antenna

(zur Lage et al., 2003)

macrochaeta | ectopic & antenna (with Df(2L)M36F-S6)

(zur Lage et al., 2003)

olfactory neuron & embryonic antennal sense organ

(Grillenzoni et al., 2007)

sensillum basiconicum & antenna

(zur Lage et al., 2003)

sensillum basiconicum & antenna (with Df(2L)M36F-S6)

(zur Lage et al., 2003)

sensory mother cell & antennal disc

(zur Lage et al., 2003)

sensory neuron | dorsal

(zur Lage et al., 2003)

trichoid sensillum of antennal segment 3

(zur Lage et al., 2003)

trichoid sensillum of antennal segment 3 (with Df(2L)M36F-S6)

(zur Lage et al., 2003)

Detailed Description

Statement

Reference

In amos¹/Df(2L)M36F-S6 adult flies, the anterior part of the antennal lobe is disrupted and glomerular borders are fuzzy, while the posterior side seems to be unaffected. ato-positive olfactory receptor neurons Ir92a and Ir75a are unaffected, with axonal projections similar to wild-type controls.

(Okumura et al., 2016)

The number of neurons in the dorsal organ ganglion are reduced in mutant embryos compared to wild type. The number of olfactory receptor neurons in the DO ganglion is reduced in the mutant embryos (average number is 12 compared to the wild-type number of 21).

(Grillenzoni et al., 2007)

Mutant embryos lack two dorsal sensory neurons per segment, including the dorsal bipolar dendritic neuron. Adults are viable as homozygotes and hemizygotes. In amos¹/Df(2L)M36F-S6 animals the third segment of the antenna is reduced because of missing basiconica and trichodea. In the pupal antennal imaginal disc of mutant animals, the first and second waves of sensory organ precursor formation appear to occur normally, but the third phase fails to occur.

(zur Lage et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

amos¹/Df(2L)M36F-S6 has macrochaeta | ectopic & antenna phenotype, suppressible by lz³⁴

(zur Lage et al., 2003)

amos¹/Df(2L)M36F-S6 has macrochaeta | ectopic & antenna phenotype, suppressible | partially by sc^10-1

(zur Lage et al., 2003)

Other

Statement

Reference

amos¹, ato¹ has sensory neuron | somatic clone phenotype

(zur Lage et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

amos¹ ; ato¹ double mutant embryos show a complete lack of olfactory receptor neurons in the dorsal organ ganglion.

(Grillenzoni et al., 2007)

When amos¹ clones are made in ato¹ animals the clone patch contains no sense organs except bristles.

(zur Lage et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

amos¹/Df(2L)M36F-S6 is partially rescued by amos^UAS.cGa/Scer\GAL4^amos.PZ

(Holohan et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

amos¹

(Ando et al., 2019, Mohapatra and Menuz, 2019, Okumura et al., 2016, Singh et al., 2013, Plavicki et al., 2012, Bardin et al., 2010, Benton et al., 2009, Grillenzoni et al., 2007, Holohan et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (10)

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