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General Information
Symbol
Dmel\amos1
Species
D. melanogaster
Name
FlyBase ID
FBal0155657
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C18596357T

Reported nucleotide change:

C550T

Amino acid change:

Q184term | amos-PA

Reported amino acid change:

Q184term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C550T.

Amino acid replacement: Q184term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In amos1/Df(2L)M36F-S6 adult flies, the anterior part of the antennal lobe is disrupted and glomerular borders are fuzzy, while the posterior side seems to be unaffected. ato-positive olfactory receptor neurons Ir92a and Ir75a are unaffected, with axonal projections similar to wild-type controls.

The number of neurons in the dorsal organ ganglion are reduced in mutant embryos compared to wild type. The number of olfactory receptor neurons in the DO ganglion is reduced in the mutant embryos (average number is 12 compared to the wild-type number of 21).

Mutant embryos lack two dorsal sensory neurons per segment, including the dorsal bipolar dendritic neuron. Adults are viable as homozygotes and hemizygotes. In amos1/Df(2L)M36F-S6 animals the third segment of the antenna is reduced because of missing basiconica and trichodea. In the pupal antennal imaginal disc of mutant animals, the first and second waves of sensory organ precursor formation appear to occur normally, but the third phase fails to occur.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

amos1/Df(2L)M36F-S6 has macrochaeta | ectopic & antenna phenotype, suppressible by lz34

amos1/Df(2L)M36F-S6 has macrochaeta | ectopic & antenna phenotype, suppressible | partially by sc10-1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

amos1 ; ato1 double mutant embryos show a complete lack of olfactory receptor neurons in the dorsal organ ganglion.

When amos1 clones are made in ato1 animals the clone patch contains no sense organs except bristles.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (9)