FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S48-5
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General Information
Symbol
Dmel\S48-5
Species
D. melanogaster
Name
FlyBase ID
FBal0155935
Feature type
allele
Associated gene
Dmel\S
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        S48-5 heterozygous mutants display a strong eye roughening phenotype and approximately 10% of ommatidia display orientation defects. Programmed cell death in the pupal eye disc (42 hours after pupal formation) is defective and a loss of interommatidial cells is observed.

        (Montrasio et al., 2007)

        S48-5/+ animals show a mild loss of photoreceptors and ommatidial rotation abnormalities.

        (Gaengel and Mlodzik, 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        S48-5 has ommatidium phenotype, enhanceable by Ras85De2F

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by pnut02502

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by pnutXP

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by shg2

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by spi1

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by spi259

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by stanE59

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by zip02957

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by zip1

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by Egfrt1

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by capt06955

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by chic01320

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by cno2

        (Gaengel and Mlodzik, 2003)

        S48-5 has ommatidium phenotype, enhanceable by cno3

        (Gaengel and Mlodzik, 2003)
        Suppressor of
        Statement
        Reference

        S[+]/S48-5 is a suppressor | partially of ommatidium phenotype of ecspok

        (Montrasio et al., 2007)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The ommatidial rotation defects observed in ecspok hemizygous adult eyes are partially suppressed by S48-5/+.

        (Montrasio et al., 2007)

        S48-5/spi259 mutants show 37.83%+-13.35 misrotated ommatidia compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/spi1 mutants show 40.04%+-3.7 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/grk3 mutants show 3.14%+-2.58 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/vnaddC6 mutants show 10.02%+-3.27 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/argosrlt mutants show 3.74%+-1.99 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/Egfrt1 mutants show 41.52%+-7.24 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/Ras85De2F mutants show 58.05%+-4.57 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/cno2 mutants show 40.56%+-7.99 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/cno3 mutants show 43.24%+-8.67 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/nmoP1 mutants show 17.38%+-5.39 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/shg2 mutants show 40.56%+-5.21 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/arm2 mutants show 12/43%+-5.66 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/stanE59 mutants show 45.59%+-7.32 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/wb09437 mutants show 13.2%+-3.05 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/wb4418 mutants show 7.17%+-0.60 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/mysunspecified mutants show 4.44%+-2.59 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/mys1 mutants show 7.64%+-3.82 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/ena02029 mutants show 7.77%+-2.95 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/pnutXP mutants show 24.58%+-5.90 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/pnut02502 mutants show 20.07%+-11.25 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/zip02957 mutants show 34.60%+-4.71 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/zip1 mutants show 19.34%+-7.06 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/Khc8 mutants show 10.38%+-5.72 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/Khck13314 mutants show 2.87%+-2.04 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/ck13 mutants show 5.41%+-2.22 misrotated ommatidia compared

        to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/capt06955 mutants show 34.19%+-8.94 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/kst01318 mutants show 5.62%+-1.13 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/scaBP1 mutants show 9.75%+-3.06 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        S48-5/chic01320 mutants show 21.90%+-5.89 misrotated ommatidia

        compared to 9.55%+-1.43 seen in S48-5 mutants alone.

        (Gaengel and Mlodzik, 2003)
        Xenogenetic Interactions
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        Complementation and Rescue Data
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        Mutant
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        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        S48-5
        S48.5
        (Montrasio et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)