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General Information
Symbol
Dmel\Psn527.D447A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0156035
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of the 527 amino acid isoform of Psn. The amino acid replacement D447A has been introduced in the coding region, to mimic a D385A change in the human ortholog.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  brain cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
This allele represents a human variant implicated in disease.

Relevance to disease not addressed.

PSEN1:p.Asp385Ala
Variants Synonym(s)
PSEN1:p.Asp381Ala
Associated human disease model(s)
    External database links
    Comments concerning this variant
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Expression of Psn527.D447A.UAS under the control of Scer\GAL4Appl.G1a leads to axonal blockages in third instar larval segmental nerves compared to controls.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhanced by
    Enhancer of
    Suppressor of
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Expression of Psn527.D447A.GMR suppresses the Hsap\APP695.Scer\UAS-induced cell death seen upon expression in the developing wing (under the control of Scer\GAL4ptc-559.1).

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (3)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Psn527.D447A.Scer\UAS
    Psn527.D447A.UAS
    Name Synonyms
    Secondary FlyBase IDs
      References (6)