FlyBase Allele Report: Dmel\Fak[KG00304]

General Information

Symbol

Dmel\Fak^KG00304

Species

D. melanogaster

Name

FlyBase ID

FBal0156459

Feature type

allele

Associated gene

Dmel\Fak

Associated Insertion(s)

P{SUPor-P}Fak^KG00304

Carried in Construct

Also Known As

Fak56^KG, Fak56^KG00304

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Tsai et al., 2008)

Mutagen

P-element activity

(FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Fak^KG00304

Cytology

Description

P{SUPor-P} insertion 373bp upstream of the Fak56D ATG codon.

(Grabbe et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,436,970..19,436,970 [+]

(Jin et al., 2020, Grabbe et al., 2004, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^4xA.UAS.2N4R

(Dourlen et al., 2017)

modeled by Hsap\MAPT^UAS.cWa

(Dourlen et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with Fak^CG1)

(Jin et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

The neuromuscular junction is normal in Fak^N30/Fak^KG00304 third instar larvae.

(Tsai et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Fak^N30/Fak^KG00304, Nf1[+]/Nf1^E2 has abnormal neuroanatomy | larval stage phenotype

(Tsai et al., 2012)

rut[+]/Adcy1^rut-1, Fak^N30/Fak^KG00304 has abnormal neuroanatomy | larval stage phenotype

(Tsai et al., 2012)

Fak^N30/Fak^KG00304, scb²/scb[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Src64B[+]/Src64B^PI has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Itgbn¹/betaInt-nu[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, LanA^9-32/LanA[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Src42A^E1/Src42A[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2008)

Phenotype Manifest In

Other

Statement

Reference

Fak^N30/Fak^KG00304, Nf1[+]/Nf1^E2 has NMJ bouton | increased number | larval stage phenotype

(Tsai et al., 2012)

rut[+]/Adcy1^rut-1, Fak^N30/Fak^KG00304 has NMJ bouton | increased number | larval stage phenotype

(Tsai et al., 2012)

Fak^N30/Fak^KG00304, scb²/scb[+] has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Src42A^E1/Src42A[+] has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Src64B[+]/Src64B^PI has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Src64B[+]/Src64B^PI has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, scb²/scb[+] has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Itgbn¹/betaInt-nu[+] has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Itgbn¹/betaInt-nu[+] has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, LanA^9-32/LanA[+] has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Src42A^E1/Src42A[+] has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Fak^N30/Fak^KG00304 ; Nf1^E2/+ and rut¹/+ ; Fak^N30/Fak^KG00304 larvae show an increase in bouton number per muscle area at the neuromuscular junction compared to wild type.

(Tsai et al., 2012)

Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in Fak^N30/Fak^KG00304 third instar larvae which are also heterozygous for one of βInt-ν¹, scb², Src42A^E1 or Src64B^PI.

Significant overgrowth of the NMJ (increased bouton number per muscle area) is seen in LanA^9-32/+ Fak^N30/Fak^KG00304 third instar larvae.

No significant overgrowth of the neuromuscular junction is seen in Fak^N30/Fak^KG00304 third instar larvae which are also heterozygous for one of mew¹, if^k27e, mys¹ or wb^4Y18.

(Tsai et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

13080

y¹ w^67c23; P{SUPor-P}Fak^KG00304

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Fak56^KG00304

(Tsai et al., 2012, Tsai et al., 2008)

Fak56^KG

(Tsai et al., 2012, Tsai et al., 2008)

Fak56D^KG00304

Fak^KG00304

(Orr et al., 2022, Jin et al., 2020, Dourlen et al., 2017)

Fak^KG304

(Orr et al., 2022)

Fak^KG

(Dourlen et al., 2017, Tsai et al., 2008)

dFAK^KG00304

(Macagno et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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