FlyBase Allele Report: Dmel\Eip74EF[BG01805]

General Information

Symbol

Dmel\Eip74EF^BG01805

Species

D. melanogaster

Name

FlyBase ID

FBal0156470

Feature type

allele

Associated gene

Dmel\Eip74EF

Associated Insertion(s)

P{GT1}Eip74EF^BG01805

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{GT1}Eip74EF^BG01805

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GT1}

gene trap

polyA trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:17,577,799..17,577,799 [-]

(Liu et al., 2012, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Liu et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

The lifespan of Eip74EF^BG01805 mutant flies is similar to controls.

(Liu et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Eip74EF^BG01805 is a suppressor | partially of short lived phenotype of Fmr1^+tLa, mir-277^+tLa, mir-34^null

(Liu et al., 2012)

Eip74EF^BG01805 is a suppressor | partially of abnormal neuroanatomy | conditional phenotype of Fmr1^+tLa, mir-277^+tLa, mir-34^null

(Liu et al., 2012)

NOT Suppressor of

Statement

Reference

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of short lived phenotype of Fmr1^+tLa, mir-277^+tLa, mir-34^null

(Liu et al., 2012)

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of abnormal neuroanatomy | conditional phenotype of Fmr1^+tLa, mir-277^+tLa, mir-34^null

(Liu et al., 2012)

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of abnormal neuroanatomy | conditional phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Eip74EF^BG01805 is a suppressor | partially of adult brain | conditional phenotype of Fmr1^+tLa, mir-277^+tLa, mir-34^null

(Liu et al., 2012)

NOT Suppressor of

Statement

Reference

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of adult brain | conditional phenotype of Fmr1^+tLa, mir-277^+tLa, mir-34^null

(Liu et al., 2012)

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of adult brain | conditional phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of ommatidium | conditional phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Eip74EF[+]/Eip74EF^BG01805 is a non-suppressor of photoreceptor | conditional phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous Eip74EF^BG01805 partially suppresses the age-associated defects seen in mir-34^null mutants (expressing mir-277^+tLa and Fmr1^+tLa to restore mir-277 and Fmr1 function respectively). The shortened lifespan and increased brain vacuolisation are both rescued. One copy of Eip74EF^BG01805 is unable to suppress these phenotypes.

(Liu et al., 2012)

Xenogenetic Interactions

Statement

Reference

One copy of Eip74EF^BG01805 has little effect on the degeneration seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ninaE.PT.

(Liu et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12619

w¹¹¹⁸; P{GT1}Eip74EF^BG01805

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

E74A^BG01805

(Liu et al., 2012)

E74A^BG

(Liu et al., 2012)

Eip74EF^BG01805

(Liu et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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