Injection of Dcr-2R416X mutant flies with Invertebrate Iridescent Virus type 6 (IIV-6) leads to a more rapid and intense appearance of blue colour, which is characteristic of the accumulation of iridescent viral particles, than in wild-type control. Dcr-2R416X mutant flies are significantly more susceptible to IIV-6 infection than are wild-type. A fraction of Dcr-2R416X flies injected with buffer also die in the course of the experiment, indicating an increased sensitivity to stress associated with the mutation. The decreased survival time correlated with a 20-fold increased viral load in Dcr-2R416X mutant flies at 10 d post-infection.
Dcr-2R416X mutant flies show severely compromised survival when infected with vesicular stomatitis virus, and die within 12 days of infection. Viral titres are significantly higher compared to controls.