Open Close
General Information
Symbol
Dmel\Dcr-2R416X
Species
D. melanogaster
Name
FlyBase ID
FBal0156732
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C17579505T

Amino acid change:

R416term | Dcr-2-PA; R416term | Dcr-2-PB

Reported amino acid change:

R416term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R416term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Injection of Dcr-2R416X mutant flies with Invertebrate Iridescent Virus type 6 (IIV-6) leads to a more rapid and intense appearance of blue colour, which is characteristic of the accumulation of iridescent viral particles, than in wild-type control. Dcr-2R416X mutant flies are significantly more susceptible to IIV-6 infection than are wild-type. A fraction of Dcr-2R416X flies injected with buffer also die in the course of the experiment, indicating an increased sensitivity to stress associated with the mutation. The decreased survival time correlated with a 20-fold increased viral load in Dcr-2R416X mutant flies at 10 d post-infection.

Dcr-2R416X mutant flies show severely compromised survival when infected with vesicular stomatitis virus, and die within 12 days of infection. Viral titres are significantly higher compared to controls.

Dcr-2R416X/+ significantly suppresses the position effect variegation of the Sb1 allele that is seen in the T(2;3)SbV chromosome.

Dcr-2L811fsX/Dcr-2R416X suppresses the position effect variegation of the w gene that is seen in the In(1)wm4 chromosome.

flies show a slight disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

Dcr-2R416X is a suppressor of eye phenotype of wIR.GMR

Dcr-2R416X is a suppressor of pigment cell phenotype of wIR.GMR

Additional Comments
Genetic Interactions
Statement
Reference

Dcr-2R416X ; Dcr-1Q1147X/+ females have normal ovaries and normal fertility.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (14)