FlyBase Allele Report: Dmel\Adar[E374A]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Adar^E374A

General Information

Symbol

Dmel\Adar^E374A

Species

D. melanogaster

Name

FlyBase ID

FBal0360098

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypermorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

hypermorphic allele - molecular evidence

(Deng et al., 2020)

Mutagen

(Zhang et al., 2017)

Progenitor genotype

Cytology

Description

Amino acid replacement: E374A.

(Zhang et al., 2017)

Nucleotide substitution: C1725T.

(Zhang et al., 2017)

Nucleotide substitution: A1733C.

(Zhang et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Deng et al., 2020)

paralytic | adult stage | heat sensitive

(Deng et al., 2020)

(Deng et al., 2020)

Phenotype Manifest In

(Deng et al., 2020)

retina | adult stage

(Deng et al., 2020)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Adar^E374A has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by Dcr-2^R416X

(Deng et al., 2020)

Suppressed by

Statement

Reference

Adar^E374A has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa

(Deng et al., 2020)

NOT suppressed by

Statement

Reference

Adar^E374A has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Dcr-2^R416X

(Deng et al., 2020)

Other

Statement

Reference

Adar^E374A, Adar^GD1355, Hsap\ADARB1^UAS.cKa, Scer\GAL4^ChAT.7.4 has abnormal locomotor behavior | adult stage phenotype

(Deng et al., 2020)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Adar^E374A is partially rescued by Scer\GAL4^ChAT.7.4/Adar^3.4.UAS

(Deng et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Adar E374A

(Zhang et al., 2017)

Adar EA

(Zhang et al., 2017)

Adar^E374A

(Deng et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections