FlyBase Allele Report: Dmel\park[UAS.cHa]

General Information

Symbol

Dmel\park^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Haywood

FlyBase ID

FBal0158828

Feature type

allele

Associated gene

Dmel\park

Associated Insertion(s)

Carried in Construct

P{UAS-parkin.H}

Key Links

Transgenic product class

cDNA

(Haywood and Staveley, 2004)

wild_type

(Haywood and Staveley, 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Haywood and Staveley, 2004)

wild_type

(Haywood and Staveley, 2004)

Mutagen

in vitro construct

(Haywood and Staveley, 2004)

Progenitor genotype

Carried in construct

P{UAS-parkin.H}

Cytology

Description

UASt sequences drive expression of the SD01679 park cDNA.

(Haywood and Staveley, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

park

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Haywood and Staveley, 2004)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

When park^Scer\UAS.cHa is driven by Scer\GAL4^GMR.PF no effect on the ey is seen. When park^Scer\UAS.cHa is driven by Scer\GAL4^Ddc.PL no effect is seen on the climbing ability of the mutant flies.

(Haywood and Staveley, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

park^UAS.cHa, Scer\GAL4^Act5C.PU is a suppressor | partially of partially lethal - majority die phenotype of PolG1^KK100485, Scer\GAL4^Act5C.PU

(Humphrey et al., 2012)

park^UAS.cHa, Scer\GAL4^Act5C.PU is a suppressor | partially of some die during larval stage phenotype of PolG1^KK100485, Scer\GAL4^Act5C.PU

(Humphrey et al., 2012)

park^UAS.cHa, Scer\GAL4^Act5C.PU is a suppressor | partially of some die during pupal stage phenotype of PolG1^KK100485, Scer\GAL4^Act5C.PU

(Humphrey et al., 2012)

park^UAS.cHa, Scer\GAL4^GMR.PF is a suppressor of abnormal locomotor behavior phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF

(Haywood and Staveley, 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

park^UAS.cHa, Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF

(Haywood and Staveley, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of park^Scer\UAS.cHa partially suppresses the lethality seen when tam^KK100485 is expressed under the control of Scer\GAL4^Act5C.PU.

(Humphrey et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

park^Scer\UAS.cHa

park^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Haywood

(Haywood and Staveley, 2004)

Secondary FlyBase IDs

References (2)

Report Sections

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