FlyBase Allele Report: Dmel\Pka-R1[E1]

General Information

Symbol

Dmel\Pka-R1^E1

Species

D. melanogaster

Name

FlyBase ID

FBal0160014

Feature type

allele

Associated gene

Dmel\Pka-R1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Yoshida et al., 2004)

Mutagen

ethyl methanesulfonate

(Yoshida et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: G293D.

(Yoshida et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:20,833,626..20,833,626 [+]

Nucleotide change:

G20833626A

Amino acid change:

Reported amino acid change:

G293D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Yoshida et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | maternal effect (with Df(3L)ME107)

(Yoshida et al., 2004)

lethal | maternal effect (with Df(3L)ri^XT106)

(Yoshida et al., 2004)

lethal | maternal effect (with Df(3L)ri-XT1)

(Yoshida et al., 2004)

Phenotype Manifest In

embryonic/first instar larval cuticle | maternal effect (with Pka-R1¹⁸³⁰⁴)

(Yoshida et al., 2004)

embryonic abdominal segment | maternal effect (with Pka-R1¹⁸³⁰⁴)

(Yoshida et al., 2004)

embryonic head | maternal effect (with Pka-R1¹⁸³⁰⁴)

(Yoshida et al., 2004)

Detailed Description

Statement

Reference

Embryos from Pka-R1¹⁸³⁰⁴/Pka-R1^E1 mothers have patterning defects ranging from deletion of the head to complete mirror-image duplication of posterior structures (abdominal segments and filzkorper material).

(Yoshida et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Pka-R1^E1/Pka-R1¹⁸³⁰⁴ has embryonic abdominal segment | germline clone | maternal effect phenotype, suppressible by Pka-C1[+]/Pka-C1^E95

(Yoshida et al., 2004)

Pka-R1^E1/Pka-R1¹⁸³⁰⁴ has embryonic abdominal segment | germline clone | maternal effect phenotype, suppressible by Pka-C1[+]/Pka-C1^H2

(Yoshida et al., 2004)

Pka-R1^E1/Pka-R1¹⁸³⁰⁴ has embryonic head | germline clone | maternal effect phenotype, suppressible by Pka-C1[+]/Pka-C1^E95

(Yoshida et al., 2004)

Pka-R1^E1/Pka-R1¹⁸³⁰⁴ has embryonic head | germline clone | maternal effect phenotype, suppressible by Pka-C1[+]/Pka-C1^H2

(Yoshida et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype of embryos from osk⁹/osk⁶ mothers is unaffected by the mothers carrying Pka-R1¹⁸³⁰⁴/Df(3L)ME107.

(Yoshida et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pka-R1^E1 is rescued by Pka-R1^αTub67C.PY

(Yoshida et al., 2004)

Pka-R1^E1 is rescued by Scer\GAL4^otu.PR/Pka-R1^UASp.cYa

(Yoshida et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

605264

w^*; ru¹ hry¹ Diap1^th-1 st¹ Pka-R1^E1 P{FRT(w^hs)}2A cu¹ sr¹ e^s ca¹/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pka-R1^E1

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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