FlyBase Allele Report: Dmel\GluRIIA[unspecified]

General Information

Symbol

Dmel\GluRIIA^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0160417

Feature type

allele

Associated gene

Dmel\GluRIIA

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Pawlu et al., 2004)

abnormal neurophysiology | third instar larval stage

(Genç et al., 2017)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage

(Genç et al., 2017)

Detailed Description

Statement

Reference

Recordings in GluRIIA^unspecified mutant third instar larval neuromuscular junctions under standard conditions show significantly decreased mEPSP amplitude and a robust, homeostatic increase in quantal content, but no apparent changes in EPPSP amplitude.

(Genç et al., 2017)

The mean quantal amplitude, rise time, decay time and area ratio h of excitatory postsynaptic currents are reduced in mutants.

(Pawlu et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

GluRIIA^unspecified has abnormal neurophysiology | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/Mctp^e00415/Mctp^UAS.cGa

(Genç et al., 2017)

NOT suppressed by

Statement

Reference

GluRIIA^unspecified has abnormal neurophysiology | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/Mctp^e00415/Mctp^UAS.cGa

(Genç et al., 2017)

Suppressor of

Statement

Reference

GluRIIA[+]/GluRIIA^unspecified is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of dbo^henji-1

(Wang et al., 2016)

Other

Statement

Reference

GluRIIA^unspecified, Mctp^e00415 has abnormal neurophysiology | third instar larval stage phenotype

(Genç et al., 2017)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

GluRIIA^unspecified has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/Mctp^e00415/Mctp^UAS.cGa

(Genç et al., 2017)

NOT suppressed by

Statement

Reference

GluRIIA^unspecified has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/Mctp^e00415/Mctp^UAS.cGa

(Genç et al., 2017)

Suppressor of

Statement

Reference

GluRIIA[+]/GluRIIA^unspecified is a suppressor | partially of bouton | third instar larval stage phenotype of dbo^henji-1

(Wang et al., 2016)

GluRIIA[+]/GluRIIA^unspecified is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of dbo^henji-1

(Wang et al., 2016)

Other

Statement

Reference

GluRIIA^unspecified, Mctp^e00415 has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Genç et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Although both GluRIIA^unspecified single mutants and in GluRIIA^unspecified, Mctp^e00415 double mutants show similarly decreased mEPSP amplitudes in the third instar larval neuromuscular junction, double mutants show a decrease in quantal content instead of the homeostatic increase in quantal content, and also show a decrease in EPSP amplitude; Mctp^UAS.cGa expression under the control of Scer\GAL4^elav-C155 in the double mutant background leads to homeostatic increase in quantal content as observed in GluRIIA^unspecified single mutants.

(Genç et al., 2017)

GluRIIA^unspecified/+ partially suppresses the increased satellite bouton phenotype seen in dbo^henji-1/dbo^henji-1 mutant larval neuromuscular junctions.

(Wang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

GluRIIA^unspecified

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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