FB2026_03 , released September 17, 2026
Allele: Dmel\BtkY677F.αTub67C.mGFP6
Open Close
General Information
Symbol
Dmel\BtkY677F.αTub67C.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0162745
Feature type
allele
Associated gene
Dmel\Btk
Associated Insertion(s)
Carried in Construct
P{αTub67C-Btk.Y677F.GFP}
Key Links
Transgenic product class
missense_variant
(Lu et al., 2004)
polypeptide_post_translational_processing_variant
(Lu et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lu et al., 2004)
polypeptide_post_translational_processing_variant
(Lu et al., 2004)
Mutagen
in vitro construct
(Lu et al., 2004)
Progenitor genotype
Carried in construct
P{αTub67C-Btk.Y677F.GFP}
Cytology
Description

The αTub67C promoter drives expression of the type 2 Btk isoform (longer isoform that includes a PH domain), mutated to carry a Y677F amino acid substitution and tagged at the C-terminal end with mGFP6.

(Lu et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
αTub67C
Encoded product / tool
Btk
Tagged with
mGFP6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      BtkY677F.αTub67C.mGFP6 partially rescues Btkk05610

      (Lu et al., 2004)
      Comments

      Btk29AY677F.αTub67C.T:Avic\GFP-m6, Btk29Ak05610 ovaries have significantly smaller ring canals to wild-type, or fully rescued ovaries.

      (Lu et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Btk29AY677F.αTub67C.T:Avic\GFP-m6
      Btk29AY677F.αTub67C.mGFP6
      BtkY677F.αTub67C.mGFP6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)