FlyBase Allele Report: Dmel\Btk[k05610]

(Chandrasekaran and Beckendorf, 2005, Djagaeva, 2005, Djagaeva et al., 2005, Lu et al., 2004, Spradling et al., 1999, Guarnieri et al., 1998, Roulier et al., 1998, Roulier, 1996.4.29, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

actin filament bundle | embryonic stage 17

(Öztürk-Çolak et al., 2016)

cephalopharyngeal skeleton

(Roulier et al., 1998)

dorsal bridge

(Roulier et al., 1998)

egg

(Guarnieri et al., 1998)

egg chamber

(Djagaeva, 2005)

embryonic/first instar larval cuticle (with Btk^k00206)

(Roulier et al., 1998)

embryonic/first instar larval cuticle (with Df(2L)TE29Aa-14)

(Roulier et al., 1998)

embryonic/larval tracheal dorsal trunk | embryonic stage 17

(Öztürk-Çolak et al., 2016)

embryonic/larval tracheal section

(Matusek et al., 2006)

embryonic head

(Roulier and Beckendorf, 1996)

epipharyngeal sclerite

(Roulier et al., 1998)

hypostomal sclerite

(Roulier et al., 1998)

labrum

(Roulier et al., 1998)

mouth hook | posterior

(Roulier et al., 1998)

nurse cell ring canal

(Guarnieri et al., 1998)

presumptive embryonic salivary gland

(Chandrasekaran and Beckendorf, 2005)

presumptive embryonic salivary gland (with Btk^k00206)

(Chandrasekaran and Beckendorf, 2005)

taenidial fold

(Matusek et al., 2006)

taenidial fold | embryonic stage 17

(Öztürk-Çolak et al., 2016)

vertical bridge | anterior

(Roulier et al., 1998)

Detailed Description

Statement

Reference

The tracheal dorsal trunk of Btk29A^k05610 homozygous stage 17 embryos exhibit heterogeneous patterns of hardly detected taenidial folds and F-actin bundles with stretches of perpendicular structures followed by stretches of parallel structures compared to controls.

(Öztürk-Çolak et al., 2016)

Some Btk29A^k05610 larvae display a tracheal necrosis phenotype, while others display a superficially normal-looking tracheal tree , where cuticle secretion has been completed. These larvae also show an abnormal taenidial fold pattern.

(Matusek et al., 2006)

Btk29A^k05610 embryos exhibit abnormally long salivary glands that do not fully invaginate. Btk29A^k05610/Btk29A^k00206 transheterozygotes also show this phenotype. Cell counting and monitoring of mitoses show that the long glands are not the result of recruitment of extra cells into the salivary gland primordium or from the production of extra cells during development.

(Chandrasekaran and Beckendorf, 2005)

In the ovarioles of Btk29A^k05610 germline clones, 10% contain fused egg chambers at 18^oC; this value drops to 5% at 25^oC.

(Djagaeva, 2005)

Homozygous germline clones result in dumpless and maternal effect head defect phenotypes. Some eggs are fertilised and develop to adulthood.

(Sinka et al., 2002)

28.2 +/- 3.0% of Btk29A^k00206/Btk29A^k05610 animals die as embryos.

(Tateno et al., 2000)

Females with homozygous germ line clones have defects in ring canal morphogenesis, and show a failure to completely transfer the cytoplasmic contents of the nurse cells to the oocyte. These females produce eggs ranging in size from 50% to 100% of wild-type.

(Guarnieri et al., 1998)

Homozygous embryos show defects in head involution. The head skeleton is abnormal and lacks several structures, including the dorsal bridge, anterior portions of the vertical plate, epistomal sclerite, labrum, H-piece lateral bar, and posterior portions of the mouth hook. Btk29A^k00206/Btk29A^k05610 and Btk29A^k05610/Df(2L)TE29Aa-14 embryos have an indistinguishable cuticle phenotype from homozygous embryos.

(Roulier et al., 1998)

Embryos exhibit an abnormal head skeleton due to disrupted head involution.

(Roulier and Beckendorf, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Btk^k05610/Btk^k00206 has lethal | embryonic stage phenotype, enhanceable by Src42A^myri

(Tateno et al., 2000)

Enhancer of

Statement

Reference

Btk^k05610 is an enhancer of partially lethal - majority die phenotype of DAAM^Ex1

(Matusek et al., 2006)

Btk^k05610/Btk^k00206 is an enhancer of lethal | embryonic stage | recessive phenotype of Src42A^myri

(Tateno et al., 2000)

Btk^k05610/Btk^k00206 is an enhancer of lethal | recessive phenotype of Src42A^Jp45

(Tateno et al., 2000)

Btk^k05610 is an enhancer of lethal | embryonic stage | maternal effect | recessive phenotype of Src64B^Δ17

(Roulier et al., 1998)

Suppressor of

Statement

Reference

Btk^k05610/Btk^fic-P is a suppressor of grandchildless phenotype of pcs^gs

(Sinka et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Btk^k05610/Btk^k00206, Src42A^myri has embryonic/first instar larval cuticle | dorsal phenotype, suppressible | partially by Jra^Asp.hs.sev

(Tateno et al., 2000)

Enhancer of

Statement

Reference

Btk^k05610 is an enhancer of embryonic/larval tracheal section phenotype of DAAM^Ex1

(Matusek et al., 2006)

Btk29A[+]/Btk^k05610 is an enhancer of egg chamber phenotype of Src64B^Δ17

(Djagaeva et al., 2005)

Btk^k05610 is an enhancer of egg chamber phenotype of Src64B^Δ19

(Djagaeva, 2005)

Btk29A[+]/Btk^k05610 is an enhancer of egg chamber phenotype of Src64B^PI

(Djagaeva, 2005)

Suppressor of

Statement

Reference

Btk^k05610 is a suppressor of embryonic/larval tracheal section phenotype of DAAM^C.UASp, Scer\GAL4^btl.PS

(Matusek et al., 2006)

Other

Statement

Reference

Btk^k05610/Btk^k00206, Src42A^myri has embryonic/first instar larval cuticle | dorsal phenotype

(Tateno et al., 2000)

Btk^k05610/Btk^k00206, Src42A^myri has embryo | dorsal closure stage phenotype

(Tateno et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The cuticle and semi-lethal phenotypes of DAAM^Ex1 larvae is enhanced by Btk29A^k05610.

The tracheal cuticle defects of larvae that express DAAM^{C.Scer\UAS.P\T} under the control of Scer\GAL4^btl.PS are dominantly suppressed by Btk29A^k05610.

(Matusek et al., 2006)

The amount of abnormal egg chambers is enhanced in Btk29A^k05610/+; Src64B^Δ17 mutants, compared to Src64B^Δ17 single mutants.

(Djagaeva et al., 2005)

Reducing the Btk29A dose in Src64B^PI homozygotes enhances the defective ovariole phenotype: 70% of ovarioles contain fused egg chambers in Btk29A^k05610/+; Src64B^PI mutants.

(Djagaeva, 2005)

Btk29A^k00206 Src42A^myri/Btk29A^k05610 Src42A^myri double homozygotes show complete embryonic lethality and some embryos have a dorsal open phenotype. The leading edge cells are only partially elongated during dorsal closure. The dorsal open phenotype is partially rescued by Jra^Asp.hs.sev. Dominantly enhances the lethality of Src42A^Jp45.

(Tateno et al., 2000)

Dominantly enhances the reduction in hatching rate seen in eggs derived from homozygous Src64B^Δ17 females.

(Roulier et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Btk^e482

(Guarnieri et al., 1998)

Btk^k00206

(Roulier et al., 1998)

Btk^k00206

(BDGP Project Members, 1994-1999)

Rescued by

Btk^k05610 is rescued by Btk^{K356M.ΔPH.αTub67C.mGFP6}

(Lu et al., 2004)

Partially rescued by

Btk^k05610 is partially rescued by Btk^{Y677F.αTub67C.mGFP6}

(Lu et al., 2004)

Btk^k05610 is partially rescued by Btk^hs.PR

(Roulier et al., 1998)

Comments

The embryonic lethality of Btk29A^k05610 homozygotes is partially rescued by expression of Btk29A^hs.PR.

(Roulier et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

102398

y¹ w^67c23 ; P{lacW}Btk^k05610 / CyO

Notes on Origin

Discoverer

Comments

Excision of the P{lacW} element results in reversion of the Btk29A^k05610 phenotypes.

(Guarnieri et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Btk29A⁵⁶¹⁰

(Tsarouhas et al., 2019, Tsikala et al., 2014)

Btk29A^k05610

(Tsikala et al., 2014)

Btk^k05610

Tec29⁵⁶¹⁰

(Matusek et al., 2006, Tateno et al., 2000, Roulier et al., 1998)

Tec29^K05610

(Chandrasekaran and Beckendorf, 2005)

Tec29^k05610

(Djagaeva, 2005, Djagaeva et al., 2005, Guarnieri et al., 1998)

Tec^l(2)k05610

(Lu et al., 2004)

l(2)k05610

(Baba et al., 1999, Spradling et al., 1999, Guarnieri et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (18)

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