FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snRNP-U1-70K2
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General Information
Symbol
Dmel\snRNP-U1-70K2
Species
D. melanogaster
Name
FlyBase ID
FBal0175469
Feature type
allele
Associated gene
Dmel\snRNP-U1-70K
Associated Insertion(s)
Carried in Construct
Also Known As
U1-70K2
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Salz et al., 2004)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Salz et al., 2004)

Amino acid replacement: W88term.

(Salz et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,971,200..6,971,200 [-]
Nucleotide change:

G6971200A

Reported nucleotide change:

G?A

Amino acid change:

W88term | snRNP-U1-70K-PA; W88term | snRNP-U1-70K-PC

Reported amino acid change:

W88term

Comment:

TGG to TAG

(Salz et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      snRNP-U1-70K2/+ heterozygous 5 day old adults have significantly increased electroretinogram amplitude, compared to controls; heterozygous 10 day old adults do not have any alterations in vacuolization, compared to controls.

      (Hsieh et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      snRNP-U1-70K2 has retina phenotype, suppressible by Scer\GAL4ninaE.PU/Hsap\MAPTUAS.cUa

      (Hsieh et al., 2019)
      Enhancer of
      Statement
      Reference

      snRNP-U1-70K[+]/snRNP-U1-70K2 is an enhancer of adult brain phenotype of Hsap\MAPTR406W.UAS.cUa, Scer\GAL4elav-C155

      (Hsieh et al., 2019)
      NOT Enhancer of
      Statement
      Reference

      snRNP-U1-70K[+]/snRNP-U1-70K2 is a non-enhancer of retina phenotype of Hsap\MAPTUAS.cUa, Scer\GAL4ninaE.PU

      (Hsieh et al., 2019)
      NOT Suppressor of
      Statement
      Reference

      snRNP-U1-70K[+]/snRNP-U1-70K2 is a non-suppressor of retina phenotype of Hsap\MAPTUAS.cUa, Scer\GAL4ninaE.PU

      (Hsieh et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      snf148 has no significant effect on the survival rate of snRNP70KON35/snRNP70K2;snRNP70K::Hsap\SFRS1HCterm adults. snf148 has no significant effect on the survival rate of snRNP70KON35/snRNP70K2;snRNP70K+t9 adults. snf148/Y;snRNP70KON35/snRNP70K2;snRNP70K::Hsap\SFRS1ΔRrich-HCterm adults are never recovered.

      (Salz et al., 2004)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      U1-70K2
      (Hsieh et al., 2019, Salz et al., 2004)
      snRNP-U1-70K2
      (Hsieh et al., 2019)
      snRNP70K2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)