FlyBase Allele Report: Dmel\nmo[DB24]

General Information

Symbol

Dmel\nmo^DB24

Species

D. melanogaster

Name

FlyBase ID

FBal0175564

Feature type

allele

Associated gene

Dmel\nmo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage (with Df(3L)pbl-X1)

(Merino et al., 2009)

abnormal neuroanatomy | third instar larval stage (with nmo^P1)

(Merino et al., 2009)

decreased cell size (with nmo^adk2)

(Zeng et al., 2007)

visible (with nmo^adk2)

(Zeng et al., 2007)

Phenotype Manifest In

NMJ bouton | third instar larval stage (with Df(3L)pbl-X1)

(Merino et al., 2009)

NMJ bouton | third instar larval stage (with nmo^P1)

(Merino et al., 2009)

wing

(Zeng and Verheyen, 2004)

wing blade (with nmo^adk2)

(Zeng et al., 2007)

wing vein | ectopic

(Zeng and Verheyen, 2004)

wing vein | ectopic (with nmo^adk2)

(Lee et al., 2009)

Detailed Description

Statement

Reference

Ectopic wing veins are observed in nmo^DB24/nmo^adk2 mutant animals.

(Lee et al., 2009)

Most neuromuscular junctions at muscles 6 and 7 lack branches containing more than five boutons in nmo^DB24/Df(3L)pbl-X1 third instar larvae.

The number of boutons per muscle surface area is reduced at the neuromuscular junction in nmo^DB24/nmo^P1 third instar larvae.

Quantal content at the neuromuscular junction is normal in nmo^DB24/Df(3L)Exel6279 third instar larvae.

(Merino et al., 2009)

nmo^adk2/nmo^DB24 flies have more cells per given area of the wing blade compared to controls, suggesting that the mutant cells are slightly smaller than wild-type cells. In addition, the wings are consistently larger than wild-type wings.

(Zeng et al., 2007)

nmo^DB24 homozygotes have short, broad wings with extra vein material along the longitudinal veins, and around the posterior cross vein.

(Zeng and Verheyen, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

nmo[+]/nmo^DB24 is a suppressor of mesonotum | ectopic phenotype of Axn^A2.UAS, Scer\GAL4^sd-SG29.1

(Zeng and Verheyen, 2004)

nmo^DB24/nmo^DB24 is a suppressor of mesonotum | ectopic phenotype of Axn^A2.UAS, Scer\GAL4^sd-SG29.1

(Zeng and Verheyen, 2004)

nmo[+]/nmo^DB24 is a suppressor | partially of wing phenotype of Axn^A2.UAS, Scer\GAL4^sd-SG29.1

(Zeng and Verheyen, 2004)

nmo^DB24/nmo^DB24 is a suppressor | partially of wing phenotype of Axn^A2.UAS, Scer\GAL4^sd-SG29.1

(Zeng and Verheyen, 2004)

nmo[+]/nmo^DB24 is a suppressor | partially of wing phenotype of Axn^A2.UAS, Scer\GAL4^ap-md544

(Zeng and Verheyen, 2004)

nmo^DB24/nmo^DB24 is a suppressor | partially of wing phenotype of Axn^A2.UAS, Scer\GAL4^ap-md544

(Zeng and Verheyen, 2004)

nmo^DB24/nmo^DB24 is a suppressor | partially of wing margin phenotype of Scer\GAL4^sd-SG29.1, fz2^UAS.N

(Zeng and Verheyen, 2004)

nmo^DB24/nmo^DB24 is a suppressor | partially of wing phenotype of Scer\GAL4^sd-SG29.1, fz2^UAS.N

(Zeng and Verheyen, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The transformation of wing to notum in Axn^A2.Scer\UAS; Scer\GAL4^sd-SG29.1 flies is suppressed by nmo^DB24/+, although the rescued wings are still small, misshapen and have only some longitudinal veins. The wing rescue is significantly better when nmo^DB24/nmo^DB24 is used. The severe blistering and size reduction seen in the wings of Axn^A2.Scer\UAS; Scer\GAL4^ap-md544 flies is partially rescued by nmo^DB24/+. This rescue is significantly stronger when nmo^DB24/nmo^DB24 is used. Wing size reduction and loss of wing margin structures in fz2^Scer\UAS.N; Scer\GAL4^sd-SG29.1 flies is significantly suppressed by nmo^DB24/nmo^DB24.

(Zeng and Verheyen, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

D.Bessette and E.M.Verheyen

(Zeng and Verheyen, 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nmo^DB24

(Fernandes et al., 2014, Lee et al., 2009, Merino et al., 2009, Zeng et al., 2007)

nmo^db24

(Zeng et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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