FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)gl27S3
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General Information
Symbol
Dmel\l(2)gl27S3
Species
D. melanogaster
Name
FlyBase ID
FBal0175616
Feature type
allele
Associated gene
Dmel\l(2)gl
Associated Insertion(s)
Carried in Construct
Also Known As
lgl27S3
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Brumby et al., 2004)
ethyl methanesulfonate
(Brumby et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      l(2)gl27S3 mutant egg chamber clones display epithelial polarity defects.

      Expression of l(2)glS656A.S664A.Scer\UAS.T:Avic\GFP in a l(2)gl27S3 mutant background under the control of Scer\GAL4GR1 alters planar spindle orientation during follicle cell division. The spindle axis is nearly perpendicular to the epithelial layer.

      (Carvalho et al., 2015)

      Lethal phase is during the third larval instar.

      (Brumby et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      l(2)gl27S3, scrib1/scrib5 has lethal | dominant phenotype

      (Brumby et al., 2004)

      l(2)gl[+]/l(2)gl27S3, scrib1/scrib5 has lethal phenotype

      (Brumby et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      l(2)gl[+]/l(2)gl27S3 is a suppressor of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      l(2)gl27S3 is rescued by l(2)glUAS.GFP(S65T)/Scer\GAL4GR1

      (Carvalho et al., 2015)

      l(2)gl27S3 is rescued by l(2)glS656A.S660A.UAS.GFP

      (Carvalho et al., 2015)

      l(2)gl27S3 is rescued by l(2)glS656A.S664A.UAS.GFP

      (Carvalho et al., 2015)
      Not rescued by

      l(2)gl27S3 is not rescued by l(2)gl3A.UAS.GFP(S65T)/Scer\GAL4GR1

      (Carvalho et al., 2015)

      l(2)gl27S3 is not rescued by l(2)glS660A.S664A.UAS.GFP/Scer\GAL4GR1

      (Carvalho et al., 2015)
      Comments

      Expression of l(2)glScer\UAS.T:Avic\GFP-S65T under the control of Scer\GAL4GR1 rescues the epithelial polarity defects seen in l(2)gl27S3 mutant egg chamber clones.

      Expression of l(2)gl3A.Scer\UAS.T:Avic\GFP-S65T under the control of Scer\GAL4GR1 does not rescue the epithelial polarity defects seen in l(2)gl27S3 mutant egg chamber clones.

      Expression of l(2)glS660A.S664A.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GR1 fails to rescue epithelial polarity defects seen in l(2)gl27S3 mutant egg chamber clones.

      Expression of l(2)glS656A.S660A.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GR1 rescues the epithelial polarity defects seen in l(2)gl27S3 mutant egg chamber clones.

      Expression of l(2)glS656A.S664A.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GR1 rescues the epithelial polarity defects seen in l(2)gl27S3 mutant egg chamber clones.

      (Carvalho et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      "X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative.

      (Brumby et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (12)