FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gig4A.αTub
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General Information
Symbol
Dmel\gig4A.αTub
Species
D. melanogaster
Name
FlyBase ID
FBal0175674
Feature type
allele
Associated gene
Dmel\gig
Associated Insertion(s)
Carried in Construct
P{αTub-gig.4A}
Also Known As
Tsc24A
Key Links
Transgenic product class
missense_variant
(Dong and Pan, 2004)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Dong and Pan, 2004)
Mutagen
in vitro construct
(Dong and Pan, 2004)
Progenitor genotype
gigαTub.PD
(Dong and Pan, 2004)
Carried in construct
P{αTub-gig.4A}
Cytology
Description

Amino acid replacement: T437A. Amino acid replacement: S924A. Amino acid replacement: T1054A. Amino acid replacement: T1518A.

(Dong and Pan, 2004)
Allele components
Component
Use(s)
Encoded product / tool
gig
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      gig4A.αTub is a non-suppressor of eye phenotype of AktUAS.Tag:HA,Tag:MyrPalm(Lck), Scer\GAL4GMR.PF

      (Dong and Pan, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      PRAS40KO, Tsc1S533A.Tub, gig4A.αTub flies are viable and normal in size.

      (Pallares-Cartes et al., 2012)

      Tsc129 gig192 double mutants carrying both Tsc1S533A.Tub and gig4A.αTub are viable and normal in size, although they show a slight reduction in lipid levels compared to wild type.

      (Schleich and Teleman, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      TSC2(4A)
      (Pallares-Cartes et al., 2012)
      Tsc24A
      (Schleich and Teleman, 2009, Dong and Pan, 2004)
      Tsc2T437A/S924A/T1054A/T1518A
      (Schleich and Teleman, 2009)
      gig4A.αTub
      Name Synonyms
      Secondary FlyBase IDs
        References (3)